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Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

murF

Organism
Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 118ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSKED446469:G1GGO-2243-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Alternative name(s):
D-alanyl-D-alanine-adding enzymeUniRule annotation
Gene namesi
Name:murFUniRule annotation
Ordered Locus Names:Sked_22840Imported
OrganismiSanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)Imported
Taxonomic identifieri446469 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesSanguibacteraceaeSanguibacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi446469.Sked_22840

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 73Mur_ligaseInterPro annotationAdd BLAST43
Domaini110 – 297Mur_ligase_MInterPro annotationAdd BLAST188
Domaini319 – 402Mur_ligase_CInterPro annotationAdd BLAST84

Sequence similaritiesi

Belongs to the MurCDEF family. MurF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EES Bacteria
COG0770 LUCA
HOGENOMiHOG000268120
KOiK01929
OMAiSYNNHWG
OrthoDBiPOG091H00FE

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_02019 MurF, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR035911 MurE/MurF_N
IPR005863 UDP-N-AcMur_synth
PfamiView protein in Pfam
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
SSF63418 SSF63418, 1 hit
TIGRFAMsiTIGR01143 murF, 1 hit

Sequencei

Sequence statusi: Complete.

D1BIM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLTAAEVA DLTGGTLAAP HTTRVHGPTV VDSRKVSAGA LFVALVGESS
60 70 80 90 100
DGHDHAAGAV ADGAALVLAS RELDGLPCVV VDDVTRALGL VAAEHLRRLR
110 120 130 140 150
ASGPLQVAAV TGSVGKTTTK DLLGHVLSES GPTVMPRASF NNEIGLPLTV
160 170 180 190 200
LEAGPETRYL VLEMGASAPG DLTYLTGIAP PDVSIVLAVG AAHLGGFGGL
210 220 230 240 250
DGVARAKSEI VTGLRPEGVA VLNADDHRVV AMRDLAPSRV VTFGTVRDAG
260 270 280 290 300
VRAHRVSVDR LGRVSCQVVV GERTADLSLR LVGEHHLTNA LAALTAAVEL
310 320 330 340 350
GVDLDTAAAL VSSVDAASPH RMAVTERPDG VTVIDDSYNA NPDSMRAALK
360 370 380 390 400
ALAVVAGRDR RSVAVLGEML ELGPDSRDQH DEIGRLVVRL NIKLLVVVGA
410 420 430 440 450
GASGLADGAT QEGSWGEEVV EVEDVPAAER FLAEELRSGD VVLVKSSNGS
460
GLWRLGDALT AVTS
Length:464
Mass (Da):47,650
Last modified:January 19, 2010 - v1
Checksum:i1F2A4BC78AFF2AB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001819 Genomic DNA Translation: ACZ22199.1
RefSeqiWP_012867268.1, NC_013521.1

Genome annotation databases

EnsemblBacteriaiACZ22199; ACZ22199; Sked_22840
KEGGiske:Sked_22840

Similar proteinsi

Entry informationi

Entry nameiD1BIM2_SANKS
AccessioniPrimary (citable) accession number: D1BIM2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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