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D1BI57 (D1BI57_SANKS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Sked_00580
OrganismSanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74) [Complete proteome] [HAMAP] EMBL ACZ20031.1
Taxonomic identifier446469 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Sanguibacteraceae › Sanguibacter

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6711Zinc By similarity HAMAP MF_00172
Metal binding6731Zinc By similarity HAMAP MF_00172
Metal binding7561Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
D1BI57 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 7838D7A7C996E161

FASTA78584,187
        10         20         30         40         50         60 
MTTHTELSSD QQNPTFAAFP AATILGYPRI GPRRELKKAV ESFWAGRIDA DQLEETAAAL 

        70         80         90        100        110        120 
RKSTRDRLVA LGLSATDGSV PETFSYYDQV LDAAVTVGAV PERFATEGDL DLAGYFRAAR 

       130        140        150        160        170        180 
GEGDDAPLEM TKWFDTNYHY LVPEIGPSTT FRLASDRVVR QFAEALADGV TTRPVLVGPV 

       190        200        210        220        230        240 
TFLLLSKAAD DAPAGFEPLS RLADLLPVYA ELLRALAAAG ATWVQLDEPG LVTDTIDVPL 

       250        260        270        280        290        300 
GDVLTAVTEA YRVLSTELAR PERPAILLAA PFGDLQEALP VVAGTDVEAL AVDLVKGSAP 

       310        320        330        340        350        360 
TSPVRGLESK TLVGGVVDGH NIWRADLSAR LEVLEALEGL GAGAVAVGTS TSLQHVPHDV 

       370        380        390        400        410        420 
ADEPALDPTL ASWLAFADQK VAEVVTLAEG LREGREAVHE QLLAASAAVS SRATAAGVSV 

       430        440        450        460        470        480 
AAVRERTAAL TDGDFHRGPA QERRDAQQER LDLPLLPSTT IGSFPQTVEI RKARAAHAKG 

       490        500        510        520        530        540 
ELSLEAYEDA MRAEIQQVVE LQERIGIDVL VHGEAERNDM VQYFAELLDG FAVTQNGWVQ 

       550        560        570        580        590        600 
SYGSRCTRPS ILWGDVSRPA PMTVRWTEYT QSLTTKPVKG MLTGPVTIMA WSFVRDDIPL 

       610        620        630        640        650        660 
GETANQIGLA LRDEIADLEA AGIAIIQVDE PALRELLPLR RADQPAYLDW SVGSFTLSTA 

       670        680        690        700        710        720 
GVRPDTQIHT HLCYSEFGEV IGAIDALDAD VTSIEAARSR MEILPDLNAS GFSRGVGPGV 

       730        740        750        760        770        780 
YDIHSPRVPS QEEVTELLEL AVKSVDPALL WVNPDCGLKT RGYAETTPSL EHLVGAAKAV 


RSQLG

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001819 Genomic DNA. Translation: ACZ20031.1.
RefSeqYP_003312865.1. NC_013521.1.

3D structure databases

ProteinModelPortalD1BI57.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8631696.
GenomeReviewsGene locus Sked_00580 in contig CP001819_GR.
KEGGske:Sked_00580.
PATRIC32388546. VBISanKed123513_0053.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARNIWRAN.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD1BI57_SANKS
AccessionPrimary (citable) accession number: D1BI57
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: December 14, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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