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D1BI12 (D1BI12_SANKS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length883 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1411O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
D1BI12 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 0D7AD889C6C50191

FASTA88398,072
        10         20         30         40         50         60 
MTDDLTPEPS TPEILGENGL AIEHGRIQSV DLQLEMQRSY LDYAMSVIVG RALPEVRDGL 

        70         80         90        100        110        120 
KPVHRRVLYA MYDGGYRPDR AFSKCSRVVG DVMGKFHPHG DTAIYDALVR LVQDWSLRYP 

       130        140        150        160        170        180 
LVAGQGNFGS PGNDPAAAPR YTECRMAPIA MEMVRDIDKD TVDFQDNYDG RTQEPSILPS 

       190        200        210        220        230        240 
RFPNLLVNGS SGIAVGMATN IPPHNLREVA EGVQWYLDHP DASPEEVLDS LIRIIKGPDF 

       250        260        270        280        290        300 
PTGATILGHR GIEDAYRTGR GSITMRAIVN VEEIQNRICL VVTELPYQVN PDTLALKIAE 

       310        320        330        340        350        360 
LVKDGRVQGI ADIRDETSGR TGQRLVIVLK RDAVAKVVLN NLYKHTQLQD NFGANMLALV 

       370        380        390        400        410        420 
DGVPRTLSID AFIRHWVAHQ LEVIVRRTAF LLREAESKIH IFRGYLKALD RLDDVIALIR 

       430        440        450        460        470        480 
RSPDADRARQ GLIEMLDIDE IQATAILNMQ LRRLAALQRQ EIIDEHDKLE KEILEYQDIL 

       490        500        510        520        530        540 
AKESRQRQIV SDELNELVAK YGDERRTTVL PHAGEVSMED LIAEEEMVVT ITRGGYAKRT 

       550        560        570        580        590        600 
RSDNYRAQKR GGKGVRGAQL REDDIVDHFF VTTTHHWLLF FTNLGRVYRA KAYELPEGGR 

       610        620        630        640        650        660 
DAKGQHVANL LAFQPGEKIA QVLDLRDYDV ADYLVLATRR GTVKKTRLSE YDSNRSGGVI 

       670        680        690        700        710        720 
AINLREDADG QPDELVSARL VDATDDLILV SRKGQSIRFT ASDEAMRPLG RATSGVTGMK 

       730        740        750        760        770        780 
FREDDELLAM DVVRDGAHLF VVTEGGFAKR TSVDEYRVQG RGGLGIKVAN LVEARGDLVG 

       790        800        810        820        830        840 
ALVTDEDDEV LVIMERGKIV RSAVNQVHLT GRTTQGVTFA KPDKNDRIIA VARNVERNLG 

       850        860        870        880 
DDIDSEESGE GSDGGAVTTS DDQQHPDDAV VTPDLSTGSE EDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001819 Genomic DNA. Translation: ACZ19986.1.
RefSeqYP_003312820.1. NC_013521.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ19986; ACZ19986; Sked_00070.
GeneID8631646.
KEGGske:Sked_00070.
PATRIC32388448. VBISanKed123513_0007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.

Enzyme and pathway databases

BioCycSKED446469:GHD3-7-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD1BI12_SANKS
AccessionPrimary (citable) accession number: D1BI12
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info