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D1BEV7

- D1BEV7_SANKS

UniProt

D1BEV7 - D1BEV7_SANKS

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Protein

Phosphoribosylformylglycinamidine synthase subunit PurQ

Gene
purQ, Sked_35050
Organism
Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL By similarity.UniRule annotation

Catalytic activityi

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.UniRule annotationSAAS annotations
L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Nucleophile By similarityUniRule annotation
Active sitei201 – 2011 By similarityUniRule annotation
Active sitei203 – 2031 By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, LigaseUniRule annotationSAAS annotations

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSKED446469:GHD3-3499-MONOMER.
UniPathwayiUPA00074; UER00128.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthase subunit PurQUniRule annotation (EC:6.3.5.3UniRule annotation)
Short name:
FGAM synthaseUniRule annotation
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase subunit I
Glutaminase PurQ
Phosphoribosylformylglycinamidine synthase subunit I
Gene namesi
Name:purQUniRule annotation
Ordered Locus Names:Sked_35050Imported
OrganismiSanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)Imported
Taxonomic identifieri446469 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeSanguibacteraceaeSanguibacter
ProteomesiUP000000322: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Heterodimer of two subunits, PurQ and PurL By similarity.SAAS annotations
Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD1BEV7.

Family & Domainsi

Sequence similaritiesi

Contains glutamine amidotransferase type-1 domain.SAAS annotations
Contains glutamine amidotransferase type-domain.

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotations

Phylogenomic databases

HOGENOMiHOG000238240.
KOiK01952.
OMAiKFICRPV.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00421. PurQ.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010075. PRibForGlyAmidine_synth_I.
[Graphical view]
PIRSFiPIRSF001586. FGAM_synth_I. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01737. FGAM_synth_I. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1BEV7-1 [UniParc]FASTAAdd to Basket

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MSDVLTGARI GVITFPGTLD DRDAARAVRI AGATAVPLWH ADADLHGVDA    50
VVLPGGFSYG DYLRAGAISR FAPVMDVLVD AAKGGLPVLG ICNGFQILTE 100
SHLLPGSMIK NDSLSFLCRE QRLTVENADT AWTRGFRAGQ EITIPLKNQD 150
GQFVADEHTL DELEGEGRVV FRYAGENPNG SRRGIAGITN AAGNVVGLMP 200
HPEHAVEVGF GTAAEAGPRA GTDGLTFFTS VLGTLVTA 238
Length:238
Mass (Da):24,941
Last modified:January 19, 2010 - v1
Checksum:iBD8DB58913F80F73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001819 Genomic DNA. Translation: ACZ23393.1.
RefSeqiWP_012868461.1. NC_013521.1.
YP_003316227.1. NC_013521.1.

Genome annotation databases

EnsemblBacteriaiACZ23393; ACZ23393; Sked_35050.
GeneIDi8635138.
KEGGiske:Sked_35050.
PATRICi32395493. VBISanKed123513_3470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001819 Genomic DNA. Translation: ACZ23393.1 .
RefSeqi WP_012868461.1. NC_013521.1.
YP_003316227.1. NC_013521.1.

3D structure databases

ProteinModelPortali D1BEV7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ23393 ; ACZ23393 ; Sked_35050 .
GeneIDi 8635138.
KEGGi ske:Sked_35050.
PATRICi 32395493. VBISanKed123513_3470.

Phylogenomic databases

HOGENOMi HOG000238240.
KOi K01952.
OMAi KFICRPV.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00128 .
BioCyci SKED446469:GHD3-3499-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
HAMAPi MF_00421. PurQ.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010075. PRibForGlyAmidine_synth_I.
[Graphical view ]
PIRSFi PIRSF001586. FGAM_synth_I. 1 hit.
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR01737. FGAM_synth_I. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74.

Entry informationi

Entry nameiD1BEV7_SANKS
AccessioniPrimary (citable) accession number: D1BEV7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In Gram-negative bacteria and most eukaryotes, FGAM synthase is only formed by PurL, a single polypeptide of 140 kDa (large PurL). However in Gram-positive bacteria and archaebacteria, phosphoribosylformylglycinamidine synthase is composed of three separate proteins: PurL (small PurL), PurQ and PurS By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi