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D1B634 (D1B634_THEAS) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Taci_1244 EMBL ACZ19475.1
OrganismThermanaerovibrio acidaminovorans (strain ATCC 49978 / DSM 6589 / Su883) (Selenomonas acidaminovorans) [Reference proteome] [HAMAP] EMBL ACZ19475.1
Taxonomic identifier525903 [NCBI]
Taxonomic lineageBacteriaSynergistetesSynergistiaSynergistalesSynergistaceaeThermanaerovibrio

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 303203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 18456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2561Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2721Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D1B634 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: F2230662CF97F5CA

FASTA31634,525
        10         20         30         40         50         60 
MKVLVAYGGD SPEREVSLRS GEAVKEALSS LGWTVEGLDA DSPLRVVERA LSGAFDLVFV 

        70         80         90        100        110        120 
ALHGGWGEDG TLQCLLDTHR IPYTGPRWGA CMACMDKEIT RGVLLARGVR VPEGIPFDGS 

       130        140        150        160        170        180 
MDQGVLLELL RRWGRLVVKP CRCGSTVGIG IVDHPSRLDR ALDEAFRYDR RLVVERFIEG 

       190        200        210        220        230        240 
RELTVAVFDT PEGPKALPTV EIRPRSGFYD YSSKYTKGMT EYLCPAPLSE QEAEAVARAA 

       250        260        270        280        290        300 
VEAYRAMGCS VYSRVDVRLE EGTGEPRVLE VNTAPGMTST SLVPKAANAF GWDFPEMLRR 

       310 
ICEASLALQP GSAIPD 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001818 Genomic DNA. Translation: ACZ19475.1.
RefSeqYP_003317757.1. NC_013522.1.

3D structure databases

ProteinModelPortalD1B634.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ19475; ACZ19475; Taci_1244.
GeneID8631093.
KEGGtai:Taci_1244.
PATRIC32493840. VBITheAci125881_1245.

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycTACI525903:GH4K-1284-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1B634_THEAS
AccessionPrimary (citable) accession number: D1B634
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)