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D1B5V5 (D1B5V5_THEAS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY HAMAP-Rule MF_01465
Gene names
Name:secY HAMAP-Rule MF_01465
Ordered Locus Names:Taci_1164
OrganismThermanaerovibrio acidaminovorans (strain ATCC 49978 / DSM 6589 / Su883) (Selenomonas acidaminovorans) [Reference proteome] [HAMAP] EMBL ACZ19396.1
Taxonomic identifier525903 [NCBI]
Taxonomic lineageBacteria › Synergistetes › Synergistia › Synergistales › Synergistaceae › Thermanaerovibrio ›

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. HAMAP-Rule MF_01465

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. RuleBase RU004349 HAMAP-Rule MF_01465

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane19 – 3921Helical; By similarity HAMAP-Rule MF_01465
Transmembrane70 – 9021Helical; By similarity HAMAP-Rule MF_01465
Transmembrane118 – 13821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane142 – 16221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane171 – 19121Helical; By similarity HAMAP-Rule MF_01465
Transmembrane205 – 22521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane259 – 27921Helical; By similarity HAMAP-Rule MF_01465
Transmembrane300 – 32021Helical; By similarity HAMAP-Rule MF_01465
Transmembrane359 – 37921Helical; By similarity HAMAP-Rule MF_01465
Transmembrane383 – 40321Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
D1B5V5 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: F264698D919A2B2B

FASTA43146,599
        10         20         30         40         50         60 
MIDSFRDAFR LPDLKRRFLF LLAALFVYRL GAHIPTPGID PEAMARLFER GGVLGFFDLF 

        70         80         90        100        110        120 
AGGALSRFSI FALGVVPYIN SSIVMQLLTV IVPSLERMQK EGEEGRKRIT QYTRYGTVAF 

       130        140        150        160        170        180 
ALIQAIGMVS WLRGLGVFYG GILDGVLAMA TVTTGSVAVM WLGEVMSDHG IGNGISMLIF 

       190        200        210        220        230        240 
AGIVARIPGA IAQTFTMVRM GEMNILVVLL ALAIMVAVVA GCVMLQEGQR KIPVQYAKRV 

       250        260        270        280        290        300 
VGNRIYGGQS TYIPLRVNTA GVIPIIFASS VLLFPYTVAR FFPGAAAEAV QRAFSPGSPI 

       310        320        330        340        350        360 
YVVLYVVLIV FFAYFYTAVV FNPAELAENM KKYGGFVLGI RPGKPTADYI EKVMARITLG 

       370        380        390        400        410        420 
GALALAVVAL VPTVMSGLLN VNTFYFGGTS VLIVVGVALD TVHQLEGQLL MRHYEGILKR 

       430 
RGGKSGGLLK L

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References

[1]"Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883)."
Chovatia M., Sikorski J., Schroder M., Lapidus A., Nolan M., Tice H., Glavina Del Rio T., Copeland A., Cheng J.F., Lucas S., Chen F., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A. expand/collapse author list , Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Saunders E., Detter J.C., Brettin T., Rohde M., Goker M., Spring S., Bristow J., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Eisen J.A.
Stand. Genomic Sci. 1:254-261(2009)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49978 / DSM 6589 / Su883.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001818 Genomic DNA. Translation: ACZ19396.1.
RefSeqYP_003317678.1. NC_013522.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ19396; ACZ19396; Taci_1164.
GeneID8631012.
KEGGtai:Taci_1164.
PATRIC32493676. VBITheAci125881_1164.

Phylogenomic databases

HOGENOMHOG000080585.
KOK03076.
OMAFIMWLGE.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1B5V5_THEAS
AccessionPrimary (citable) accession number: D1B5V5
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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