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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

Pathway:iL-leucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. no protein annotated in this organism
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSDEL525898:GHVA-1548-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:Sdel_1517Imported
OrganismiSulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)Imported
Taxonomic identifieri525898 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
ProteomesiUP000002222 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotation

Protein-protein interaction databases

STRINGi525898.Sdel_1517.

Structurei

3D structure databases

ProteinModelPortaliD1B363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222940.
KOiK01704.
OMAiYLVYTDP.
OrthoDBiEOG6PZXB8.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01032. LeuD_type2.
InterProiIPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011827. LeuD_type2/HacB/DmdB.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR02087. LEUD_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

D1B363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTISGKVWC FGDNIDTDLI IAARYLNTSD PKELAKHVME DADPEFAKKV
60 70 80 90 100
GEGDIIVAGE NFGCGSSREH APIALKAAGV SAVVAKSFAR IFYRNAFNTG
110 120 130 140 150
LPIFELPNTE AIQEGESIAI SMESGEITHG SKTYKFTPIP PFMQELLDAG
160
GLMNYAQKEM KK
Length:162
Mass (Da):17,579
Last modified:January 19, 2010 - v1
Checksum:iA1CDB15E64202D1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12533.1.
RefSeqiWP_012857284.1. NC_013512.1.

Genome annotation databases

EnsemblBacteriaiACZ12533; ACZ12533; Sdel_1517.
KEGGisdl:Sdel_1517.
PATRICi32483835. VBISulDel109514_1540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12533.1.
RefSeqiWP_012857284.1. NC_013512.1.

3D structure databases

ProteinModelPortaliD1B363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525898.Sdel_1517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ12533; ACZ12533; Sdel_1517.
KEGGisdl:Sdel_1517.
PATRICi32483835. VBISulDel109514_1540.

Phylogenomic databases

HOGENOMiHOG000222940.
KOiK01704.
OMAiYLVYTDP.
OrthoDBiEOG6PZXB8.

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.
BioCyciSDEL525898:GHVA-1548-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01032. LeuD_type2.
InterProiIPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011827. LeuD_type2/HacB/DmdB.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR02087. LEUD_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51133 / DSM 6946 / 5175Imported.

Entry informationi

Entry nameiD1B363_SULD5
AccessioniPrimary (citable) accession number: D1B363
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: July 22, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.