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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Sdel_1089

Organism
Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSDEL525898:GHVA-1118-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Sdel_1089Imported
OrganismiSulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)Imported
Taxonomic identifieri525898 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
ProteomesiUP000002222 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi525898.Sdel_1089.

Structurei

3D structure databases

ProteinModelPortaliD1B1Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

D1B1Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHTPHKIIY TQVDEAPALA TYSLLPIIKA FVKRSSIKIE TRDISLSGRI
60 70 80 90 100
LAHFSDYLTN EQRVNDDLAY LGTLANTPEA NIIKLPNISA SLPQLNAAIK
110 120 130 140 150
ELQDKGYLIP SYPENPANEK EQEIKARYAK VLGSAVNPVL REGNSDRRAP
160 170 180 190 200
LCVKEYVRKN PHRMGEWHQN SRSHVAYMHE GDFYGNEKSI TMDKATTLRI
210 220 230 240 250
ELLSSEGKTT VLKEKLELLE GEIIDGTYMS ASKLAQFYET QMEEAKAQNL
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG YAVKTYFKEV FEKYAATFER LGVNANNGLG
310 320 330 340 350
DVYAKIATLP EREKNAIEAD IEACYTKRAS LAMVNSDKGI TNLHVPSDVI
360 370 380 390 400
IDASMPACIR ESGKMWGKDG ALHETKALIP DRAYARIYEE TMNFCRQNGA
410 420 430 440 450
LDPKTMGSVP NVGLMAQKAE EYGSHDKTFE IPYAGVVRMV ESENGAVLME
460 470 480 490 500
HRVEKGDIYR ACQAKDAPIR DWVKLAISRA RLSQTPAIFW LDDKRAHDAQ
510 520 530 540 550
MIKKVEHYLK AYDLSGLDIK IMSPEDAIKL SLERIVKGLD TIAVTGNVLR
560 570 580 590 600
DYLTDLFPIL EVGTSAKMLS IVPLMKGGGL FETGAGGSAP KHVQQFVEEN
610 620 630 640 650
HLRWDSLGEF MALSASLEHL STVMGNKQAA ILAKTLDSAT GKVLDEKKSP
660 670 680 690 700
SPKVGELDNR GSHFYLALYW AEALSQQDDD ENLAIAFQPL AEALRVNEKT
710 720 730 740
IVEELNSVQG KRVDLGGYYK LDVEKVNKAM RPSPTFNHAL EIFNA
Length:745
Mass (Da):82,954
Last modified:January 19, 2010 - v1
Checksum:i5ED66FBE19E81145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12113.1.
RefSeqiWP_012856871.1. NC_013512.1.

Genome annotation databases

EnsemblBacteriaiACZ12113; ACZ12113; Sdel_1089.
KEGGisdl:Sdel_1089.
PATRICi32482965. VBISulDel109514_1106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12113.1.
RefSeqiWP_012856871.1. NC_013512.1.

3D structure databases

ProteinModelPortaliD1B1Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525898.Sdel_1089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ12113; ACZ12113; Sdel_1089.
KEGGisdl:Sdel_1089.
PATRICi32482965. VBISulDel109514_1106.

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciSDEL525898:GHVA-1118-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51133 / DSM 6946 / 5175Imported.

Entry informationi

Entry nameiD1B1Z3_SULD5
AccessioniPrimary (citable) accession number: D1B1Z3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.