Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetate kinase

Gene

ackA

Organism
Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (Sdel_1045)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Active sitei150Proton donor/acceptorUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1
Sitei243Transition state stabilizerUniRule annotation1
Metal bindingi386MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 214ATPUniRule annotation5
Nucleotide bindingi284 – 286ATPUniRule annotation3
Nucleotide bindingi332 – 336ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEL525898:G1GGM-1082-MONOMER
UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Sdel_1044Imported
OrganismiSulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)Imported
Taxonomic identifieri525898 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
Proteomesi
  • UP000002222 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi525898.Sdel_1044

Structurei

3D structure databases

ProteinModelPortaliD1B1U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

D1B1U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVLNAGS SSVKFQLFNM ANNAVLASGL IEQISEPMSR TRMKYKNASG
60 70 80 90 100
VEQLIEQTAP IADHHEALKK MSLLLIESGV IHNLNDLDGI GHRVVQGGAS
110 120 130 140 150
FQAPAMVDEY VMSEIERLIP LAPLHNPGHL SGMKVSVEQS PNVPQVAIFD
160 170 180 190 200
TAFHSTLPKY AYMYALPYKY YEELRIRRYG FHGTSHRYIV KEAANYLKQD
210 220 230 240 250
INTLNAITLH LGNGASVAAI ENGKSVDTSM GLTPLEGLIM GTRSGDIDPA
260 270 280 290 300
ILFYLARKKG LTLDELDRML NKESGLKGIC GSNDMREINR LAHEGNEQAQ
310 320 330 340 350
LAREMFNYRL KKYIGSYSAV LGRVDCIVFT GGIGENDSEV RFESCSRLEN
360 370 380 390 400
FGIKIDTVRN AERTEGIRQI STDDSPVKVL VIPTNEELEI AVETMEMIEK

HCKK
Length:404
Mass (Da):44,866
Last modified:January 19, 2010 - v1
Checksum:i203FDA023F713A04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA Translation: ACZ12069.1
RefSeqiWP_012856827.1, NC_013512.1

Genome annotation databases

EnsemblBacteriaiACZ12069; ACZ12069; Sdel_1044
KEGGisdl:Sdel_1044

Similar proteinsi

Entry informationi

Entry nameiD1B1U9_SULD5
AccessioniPrimary (citable) accession number: D1B1U9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health