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Protein

Acetate kinase

Gene

ackA

Organism
Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg(2+). Can also accept Mn2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumUniRule annotation
Binding sitei14 – 141ATPUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Active sitei150 – 1501Proton donor/acceptorUniRule annotation
Sitei182 – 1821Transition state stabilizerUniRule annotation
Sitei243 – 2431Transition state stabilizerUniRule annotation
Metal bindingi386 – 3861MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2145ATPUniRule annotation
Nucleotide bindingi284 – 2863ATPUniRule annotation
Nucleotide bindingi332 – 3365ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEL525898:GHVA-1073-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Sdel_1044Imported
OrganismiSulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)Imported
Taxonomic identifieri525898 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
ProteomesiUP000002222 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD1B1U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1B1U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVLNAGS SSVKFQLFNM ANNAVLASGL IEQISEPMSR TRMKYKNASG
60 70 80 90 100
VEQLIEQTAP IADHHEALKK MSLLLIESGV IHNLNDLDGI GHRVVQGGAS
110 120 130 140 150
FQAPAMVDEY VMSEIERLIP LAPLHNPGHL SGMKVSVEQS PNVPQVAIFD
160 170 180 190 200
TAFHSTLPKY AYMYALPYKY YEELRIRRYG FHGTSHRYIV KEAANYLKQD
210 220 230 240 250
INTLNAITLH LGNGASVAAI ENGKSVDTSM GLTPLEGLIM GTRSGDIDPA
260 270 280 290 300
ILFYLARKKG LTLDELDRML NKESGLKGIC GSNDMREINR LAHEGNEQAQ
310 320 330 340 350
LAREMFNYRL KKYIGSYSAV LGRVDCIVFT GGIGENDSEV RFESCSRLEN
360 370 380 390 400
FGIKIDTVRN AERTEGIRQI STDDSPVKVL VIPTNEELEI AVETMEMIEK

HCKK
Length:404
Mass (Da):44,866
Last modified:January 19, 2010 - v1
Checksum:i203FDA023F713A04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12069.1.
RefSeqiWP_012856827.1. NC_013512.1.
YP_003304104.1. NC_013512.1.

Genome annotation databases

EnsemblBacteriaiACZ12069; ACZ12069; Sdel_1044.
KEGGisdl:Sdel_1044.
PATRICi32482873. VBISulDel109514_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA. Translation: ACZ12069.1.
RefSeqiWP_012856827.1. NC_013512.1.
YP_003304104.1. NC_013512.1.

3D structure databases

ProteinModelPortaliD1B1U9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ12069; ACZ12069; Sdel_1044.
KEGGisdl:Sdel_1044.
PATRICi32482873. VBISulDel109514_1060.

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.
BioCyciSDEL525898:GHVA-1073-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51133 / DSM 6946 / 5175Imported.

Entry informationi

Entry nameiD1B1U9_SULD5
AccessioniPrimary (citable) accession number: D1B1U9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 27, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.