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Protein

Alanine racemase

Gene

Sdel_0372

Organism
Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Sdel_0372)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Active sitei251Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei297Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSDEL525898:G1GGM-384-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Sdel_0372Imported
OrganismiSulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)Imported
Taxonomic identifieri525898 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
Proteomesi
  • UP000002222 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi525898.Sdel_0372

Structurei

3D structure databases

ProteinModelPortaliD1AZE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 342Ala_racemase_CInterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031446
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D1AZE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFITLNKAN LFHNLALLST KAGGKERVMA VLKDNAYGHG LREMAQLCCE
60 70 80 90 100
FGIKKAAVKN VEEAGVIADL FEEVLILVDQ VPLEPLAPNL SFAAHSCEML
110 120 130 140 150
EALREGSSIH LSIDTGMHRN GIKEHEIDRA MALILKKRLV FKGVFTHFRS
160 170 180 190 200
ADELSTAFFW QRSLFERAKQ RIKAFVLAHH LPEVAFHSCN SAGLLRTNSL
210 220 230 240 250
GDDAYARVGI AMYGYNTLHP SFKAYELKPV LALWAEKLST RILKRGERVG
260 270 280 290 300
YGGVYEAPCD ELISTYDIGY GDGFFRFDGI ASLAMADGRL SKGRMSMDSF
310 320 330 340
CLEGDAPKVC MFENATALAE RFQTICYEIP TKLSPSLKRI VV
Length:342
Mass (Da):37,995
Last modified:January 19, 2010 - v1
Checksum:i6880514088597B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001816 Genomic DNA Translation: ACZ11409.1
RefSeqiWP_012856175.1, NC_013512.1

Genome annotation databases

EnsemblBacteriaiACZ11409; ACZ11409; Sdel_0372
KEGGisdl:Sdel_0372

Similar proteinsi

Entry informationi

Entry nameiD1AZE2_SULD5
AccessioniPrimary (citable) accession number: D1AZE2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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