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Protein

Phosphatidylserine decarboxylase proenzyme

Gene

psd

Organism
Anaplasma centrale (strain Israel) (Anaplasma marginale subsp. centrale (strain Israel))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).UniRule annotation

Catalytic activityi

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.UniRule annotation

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphatidylserine decarboxylase proenzyme (psd)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from CDP-diacylglycerol, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotationSAAS annotation, Phospholipid metabolism
LigandPyruvateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACEN574556:G1GG7-712-MONOMER.
UniPathwayiUPA00558; UER00616.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylserine decarboxylase proenzymeUniRule annotation (EC:4.1.1.65UniRule annotation)
Cleaved into the following 2 chains:
Phosphatidylserine decarboxylase beta chainUniRule annotation
Phosphatidylserine decarboxylase alpha chainUniRule annotation
Gene namesi
Name:psdUniRule annotationImported
Ordered Locus Names:ACIS_00839Imported
OrganismiAnaplasma centrale (strain Israel) (Anaplasma marginale subsp. centrale (strain Israel))Imported
Taxonomic identifieri574556 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
Proteomesi
  • UP000000630 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotationSAAS annotation; Peripheral membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 46HelicalSequence analysisAdd BLAST34

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181Pyruvic acid (Ser); by autocatalysisUniRule annotation1

Post-translational modificationi

Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei180 – 181Cleavage (non-hydrolytic); by autocatalysisUniRule annotation2

Keywords - PTMi

ZymogenUniRule annotation

Interactioni

Subunit structurei

Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi574556.ACIS_00839.

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG41071I4. Bacteria.
COG0688. LUCA.
HOGENOMiHOG000229359.
KOiK01613.
OrthoDBiPOG091H01PZ.

Family and domain databases

HAMAPiMF_00664. PS_decarb_PSD_A. 1 hit.
InterProiView protein in InterPro
IPR003817. PS_Dcarbxylase.
IPR033175. PSD-A.
PANTHERiPTHR35809. PTHR35809. 1 hit.
PfamiView protein in Pfam
PF02666. PS_Dcarbxylase. 1 hit.
TIGRFAMsiTIGR00164. PS_decarb_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D1ASB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPSIHRHG YPFICLAFLC SCIGFALSSS LGVIFAMITA LCAYFFRDPI
60 70 80 90 100
RVIPLNDALV VSPADGVVTS IVEVESPLND GKAVTRISIF LSLFDVHVNR
110 120 130 140 150
VPVSGMVKSV EHRPGSFSSA GSGGAVNENE RVRAVIESSV GGHCIVVEQI
160 170 180 190 200
AGVLARRIVC DLESGKAAKL GSRMGIIRFG SRMNIYIPAG MPVSVAEGHT
210 220
VVGGETIIAS LDADMATVHK DLTFDKV
Length:227
Mass (Da):24,049
Last modified:January 19, 2010 - v1
Checksum:i5763F7B38E5351A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001759 Genomic DNA. Translation: ACZ49370.1.
RefSeqiWP_012880822.1. NC_013532.1.

Genome annotation databases

EnsemblBacteriaiACZ49370; ACZ49370; ACIS_00839.
KEGGiacn:ACIS_00839.

Similar proteinsi

Entry informationi

Entry nameiD1ASB7_ANACI
AccessioniPrimary (citable) accession number: D1ASB7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported