ID D1AFW9_SEBTE Unreviewed; 414 AA. AC D1AFW9; DT 19-JAN-2010, integrated into UniProtKB/TrEMBL. DT 19-JAN-2010, sequence version 1. DT 27-MAR-2024, entry version 85. DE RecName: Full=Histidine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00127}; DE EC=6.1.1.21 {ECO:0000256|HAMAP-Rule:MF_00127}; DE AltName: Full=Histidyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00127}; DE Short=HisRS {ECO:0000256|HAMAP-Rule:MF_00127}; GN Name=hisS {ECO:0000256|HAMAP-Rule:MF_00127}; GN OrderedLocusNames=Sterm_1136 {ECO:0000313|EMBL:ACZ08004.1}; OS Sebaldella termitidis (strain ATCC 33386 / NCTC 11300). OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae; OC Sebaldella. OX NCBI_TaxID=526218 {ECO:0000313|EMBL:ACZ08004.1, ECO:0000313|Proteomes:UP000000845}; RN [1] {ECO:0000313|Proteomes:UP000000845} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845}; RG US DOE Joint Genome Institute (JGI-PGF); RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., RA Mikhailova N., Sims D., Meincke L., Brettin T., Detter J.C., Han C., RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F., Hugenholtz P., RA Woyke T., Wu D., Eisen J.A.; RT "The complete chromosome of Sebaldella termitidis ATCC 33386."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACZ08004.1, ECO:0000313|Proteomes:UP000000845} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845}; RX PubMed=21304705; RA Harmon-Smith M., Celia L., Chertkov O., Lapidus A., Copeland A., RA Glavina Del Rio T., Nolan M., Lucas S., Tice H., Cheng J.F., Han C., RA Detter J.C., Bruce D., Goodwin L., Pitluck S., Pati A., Liolios K., RA Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K., Land M., RA Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Goker M., Beck B., RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., RA Klenk H.P., Chen F.; RT "Complete genome sequence of Sebaldella termitidis type strain RT (NCTC 11300)."; RL Stand. Genomic Sci. 2:220-227(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665, CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442, CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21; CC Evidence={ECO:0000256|ARBA:ARBA00001137, ECO:0000256|HAMAP- CC Rule:MF_00127}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP- CC Rule:MF_00127}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127}. CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family. CC {ECO:0000256|ARBA:ARBA00008226, ECO:0000256|HAMAP-Rule:MF_00127}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001739; ACZ08004.1; -; Genomic_DNA. DR RefSeq; WP_012860600.1; NC_013517.1. DR AlphaFoldDB; D1AFW9; -. DR STRING; 526218.Sterm_1136; -. DR KEGG; str:Sterm_1136; -. DR eggNOG; COG0124; Bacteria. DR HOGENOM; CLU_025113_1_1_0; -. DR Proteomes; UP000000845; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule. DR CDD; cd00773; HisRS-like_core; 1. DR CDD; cd00859; HisRS_anticodon; 1. DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1. DR HAMAP; MF_00127; His_tRNA_synth; 1. DR InterPro; IPR006195; aa-tRNA-synth_II. DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL. DR InterPro; IPR004154; Anticodon-bd. DR InterPro; IPR036621; Anticodon-bd_dom_sf. DR InterPro; IPR015807; His-tRNA-ligase. DR InterPro; IPR041715; HisRS-like_core. DR InterPro; IPR004516; HisRS/HisZ. DR InterPro; IPR033656; HisRS_anticodon. DR NCBIfam; TIGR00442; hisS; 1. DR PANTHER; PTHR43707:SF1; HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1. DR PANTHER; PTHR43707; HISTIDYL-TRNA SYNTHETASE; 1. DR Pfam; PF03129; HGTP_anticodon; 1. DR Pfam; PF13393; tRNA-synt_His; 1. DR PIRSF; PIRSF001549; His-tRNA_synth; 1. DR SUPFAM; SSF52954; Class II aaRS ABD-related; 1. DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1. DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1. PE 3: Inferred from homology; KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146, KW ECO:0000256|HAMAP-Rule:MF_00127}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00127}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00127}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00127}; Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00127}; KW Reference proteome {ECO:0000313|Proteomes:UP000000845}. FT DOMAIN 1..331 FT /note="Aminoacyl-transfer RNA synthetases class-II family FT profile" FT /evidence="ECO:0000259|PROSITE:PS50862" SQ SEQUENCE 414 AA; 47867 MW; 10B8BF337ACA602B CRC64; MIKVLKGMKD RYFEDIRKYD YIIDSAKNVF SKYGFEKIIT PIVEETELFE RGVGEETDVV SKEMYTFLDK AGRSITMRPE GTAGVVRAYL QAGLYKSDPL VKWFYYGPMY RYEAPQKGRY REFHQVGVEA FGVRDPFADA EIIKMGCEFL ETAGIKNLTV EINSLGNSSS RQRYTAELKK FIEERLDKLC DNCKTRYKKN PLRVLDCKSE ACQEQYKNAP VLKDYLDEES STYYEELKKY LELLEVNYVE NYRLVRGLDY YSDTVFEIKS ENLGAQSTVL AGGRYDKLLE ILGDIQMPGI GFAAGTERIA LLMDESLLKE EEKPVYVVYF PETKEYALNI IKILRENGIK VDFDYGMKSF KSQMKKAGKL NSKYVIILGE DEKNENKAVL KNFDTGEQEK LEIEKVIERV NGDV //