ID   D1ACM7_THECD            Unreviewed;      1128 AA.
AC   D1ACM7;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Tcur_3753 {ECO:0000313|EMBL:ACY99286.1};
OS   Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 /
OS   KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Thermomonospora.
OX   NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY99286.1, ECO:0000313|Proteomes:UP000001918};
RN   [1] {ECO:0000313|EMBL:ACY99286.1, ECO:0000313|Proteomes:UP000001918}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC   NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX   PubMed=21475583; DOI=10.4056/sigs.1453580;
RA   Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA   Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL   Stand. Genomic Sci. 1:13-22(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP001738; ACY99286.1; -; Genomic_DNA.
DR   RefSeq; WP_012854070.1; NC_013510.1.
DR   AlphaFoldDB; D1ACM7; -.
DR   STRING; 471852.Tcur_3753; -.
DR   KEGG; tcu:Tcur_3753; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2887; Bacteria.
DR   HOGENOM; CLU_003630_1_1_11; -.
DR   Proteomes; UP000001918; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001918}.
FT   DOMAIN          14..365
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          366..703
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          335..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         35..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1128 AA;  123729 MW;  B90C8BE20D7DCE7B CRC64;
     MITPVELARL LELPEPTPEQ ARVISAPLAP MAVIAGAGSG KSETMAARVV WLVANGLVRP
     ERVLGLTFTR KAAGELATRI RRRLDQLRDR LPQDELDRLG GEAALDGEPA VSTYHSYAAR
     LFGDHALRAA LEPTMRLISP AMAWQLAARV VDDYDGAMDG IDWRPDTVVR AVLDLSGELA
     EHLRTPEDVR EIGRRLRAQF DALPGRRGAA KNVLATQEIR ERLLPLVEAY QRAKIEREVL
     DYGDQVALAA RIARDHPDVG MIERSRYAVV LLDEYQDTSH AQLVLLTSLF GGGHPVTAVG
     DPCQSIYGWR GAGSGNLTGF PEDFPLAPAV PSRVAAVPPP RPGRRPPRHA RPAPTATLSI
     SWRNGERILE VAARIQQGLR ADTANVPRLR PGEGRRGRGR VECALLPTVT AEAEHIAERI
     RRLRAADPEL APDGLPWDEG PLKYSHIAVL VRRRSQIPPL RKALEERDIP VEVVGLGGLL
     TVPEVQDVVA TLRVVHDPTA GASLARLLTG PRWRIGPRDL VALGRRARRL ASENTRDITP
     PPDASELRPE PAANAEETDP LRQVVIELTQ ETGSLVDALD DLGDPSAYSP EGLARLRRLA
     AELRTLRSQV GLPLPDLVAE VERTLGLDIE VAARSGLDPA GARADLDAFI ETAASFAEES
     ENPTLGAFLA YLKAAESEEF GLPAGRVSES DSVKLLTVHA AKGLEWPVVV VPGLCYLPSG
     SGRPVKGSIF PSPPQQSTRW TDNPRLLPFE LRGDYEKGNL PRLNGLTKAD LDRFKDECAD
     RDLREERRLA YVAVTRASHL LIATGHRWGA TARPLHPSPF LEEIRQACET GAGRVVSWAD
     PPEEGAANPL QAEAEPGRWP ATPEGRRYAA IVEGAEMVRD AMVGRIAPWA GDDGLTEADR
     RRMTAWARDV ELLLAERDRG RGGDVLQVEL PAKLTVSTLV ALSRDPQEVA RSIRRPMPRP
     PAPYARRGTA FHRWLESRWG QQRLLDPDEL PGAADEGAAD DSMLTELQRR FEESEWASRR
     PLDIEVTFET VLGDRVLRGR MDAVFTAPDG GYEVVDWKTG RPPADEDFRH AAVQLAAYRL
     AWADLAGVPL EKVSAAFHYV RYNRTIRPAD LLDRAGLTAL LENIRPID
//