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Protein

DNA helicase

Gene

Tcur_3753

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ExonucleaseSAAS annotation, HelicaseSAAS annotationImported, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-3816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Ordered Locus Names:Tcur_3753Imported
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)Imported
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesThermomonosporaceaeThermomonospora
ProteomesiUP000001918 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi471852.Tcur_3753.

Family & Domainsi

Sequence similaritiesi

Contains uvrD-like helicase ATP-binding domain.SAAS annotation
Contains uvrD-like helicase C-terminal domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000247959.
KOiK03657.
OMAiSGHWWGP.
OrthoDBiEOG6S7XR2.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1ACM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITPVELARL LELPEPTPEQ ARVISAPLAP MAVIAGAGSG KSETMAARVV
60 70 80 90 100
WLVANGLVRP ERVLGLTFTR KAAGELATRI RRRLDQLRDR LPQDELDRLG
110 120 130 140 150
GEAALDGEPA VSTYHSYAAR LFGDHALRAA LEPTMRLISP AMAWQLAARV
160 170 180 190 200
VDDYDGAMDG IDWRPDTVVR AVLDLSGELA EHLRTPEDVR EIGRRLRAQF
210 220 230 240 250
DALPGRRGAA KNVLATQEIR ERLLPLVEAY QRAKIEREVL DYGDQVALAA
260 270 280 290 300
RIARDHPDVG MIERSRYAVV LLDEYQDTSH AQLVLLTSLF GGGHPVTAVG
310 320 330 340 350
DPCQSIYGWR GAGSGNLTGF PEDFPLAPAV PSRVAAVPPP RPGRRPPRHA
360 370 380 390 400
RPAPTATLSI SWRNGERILE VAARIQQGLR ADTANVPRLR PGEGRRGRGR
410 420 430 440 450
VECALLPTVT AEAEHIAERI RRLRAADPEL APDGLPWDEG PLKYSHIAVL
460 470 480 490 500
VRRRSQIPPL RKALEERDIP VEVVGLGGLL TVPEVQDVVA TLRVVHDPTA
510 520 530 540 550
GASLARLLTG PRWRIGPRDL VALGRRARRL ASENTRDITP PPDASELRPE
560 570 580 590 600
PAANAEETDP LRQVVIELTQ ETGSLVDALD DLGDPSAYSP EGLARLRRLA
610 620 630 640 650
AELRTLRSQV GLPLPDLVAE VERTLGLDIE VAARSGLDPA GARADLDAFI
660 670 680 690 700
ETAASFAEES ENPTLGAFLA YLKAAESEEF GLPAGRVSES DSVKLLTVHA
710 720 730 740 750
AKGLEWPVVV VPGLCYLPSG SGRPVKGSIF PSPPQQSTRW TDNPRLLPFE
760 770 780 790 800
LRGDYEKGNL PRLNGLTKAD LDRFKDECAD RDLREERRLA YVAVTRASHL
810 820 830 840 850
LIATGHRWGA TARPLHPSPF LEEIRQACET GAGRVVSWAD PPEEGAANPL
860 870 880 890 900
QAEAEPGRWP ATPEGRRYAA IVEGAEMVRD AMVGRIAPWA GDDGLTEADR
910 920 930 940 950
RRMTAWARDV ELLLAERDRG RGGDVLQVEL PAKLTVSTLV ALSRDPQEVA
960 970 980 990 1000
RSIRRPMPRP PAPYARRGTA FHRWLESRWG QQRLLDPDEL PGAADEGAAD
1010 1020 1030 1040 1050
DSMLTELQRR FEESEWASRR PLDIEVTFET VLGDRVLRGR MDAVFTAPDG
1060 1070 1080 1090 1100
GYEVVDWKTG RPPADEDFRH AAVQLAAYRL AWADLAGVPL EKVSAAFHYV
1110 1120
RYNRTIRPAD LLDRAGLTAL LENIRPID
Length:1,128
Mass (Da):123,729
Last modified:January 19, 2010 - v1
Checksum:iB90C8BE20D7DCE7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY99286.1.
RefSeqiWP_012854070.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY99286; ACY99286; Tcur_3753.
KEGGitcu:Tcur_3753.
PATRICi32517274. VBITheCur33965_3846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY99286.1.
RefSeqiWP_012854070.1. NC_013510.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471852.Tcur_3753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY99286; ACY99286; Tcur_3753.
KEGGitcu:Tcur_3753.
PATRICi32517274. VBITheCur33965_3846.

Phylogenomic databases

HOGENOMiHOG000247959.
KOiK03657.
OMAiSGHWWGP.
OrthoDBiEOG6S7XR2.

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-3816-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 1 hit.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081Imported.

Entry informationi

Entry nameiD1ACM7_THECD
AccessioniPrimary (citable) accession number: D1ACM7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: July 22, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.