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Protein
Submitted name:

UvrD/REP helicase

Gene

Tcur_3753

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, ExonucleaseSAAS annotation, HelicaseSAAS annotationImported, Hydrolase, Nuclease
Biological processDNA damage, DNA repairSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
UvrD/REP helicaseImported
Gene namesi
Ordered Locus Names:Tcur_3753Imported
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)Imported
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesThermomonosporaceaeThermomonospora
Proteomesi
  • UP000001918 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi471852.Tcur_3753

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 365UvrD-like helicase ATP-bindingInterPro annotationAdd BLAST352
Domaini366 – 703UvrD-like helicase C-terminalInterPro annotationAdd BLAST338

Sequence similaritiesi

Belongs to the helicase family. UvrD subfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4106AQX Bacteria
COG0210 LUCA
COG2887 LUCA
HOGENOMiHOG000247959
KOiK03657
OMAiSGHWWGP
OrthoDBiPOG091H0ATV

Family and domain databases

InterProiView protein in InterPro
IPR014017 DNA_helicase_UvrD-like_C
IPR000212 DNA_helicase_UvrD/REP
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
IPR011335 Restrct_endonuc-II-like
IPR014016 UvrD-like_ATP-bd
IPR034739 UvrD/AddA_N
PANTHERiPTHR11070 PTHR11070, 2 hits
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
PF00580 UvrD-helicase, 1 hit
PF13361 UvrD_C, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
SSF52980 SSF52980, 1 hit
PROSITEiView protein in PROSITE
PS51198 UVRD_HELICASE_ATP_BIND, 1 hit
PS51217 UVRD_HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

D1ACM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITPVELARL LELPEPTPEQ ARVISAPLAP MAVIAGAGSG KSETMAARVV
60 70 80 90 100
WLVANGLVRP ERVLGLTFTR KAAGELATRI RRRLDQLRDR LPQDELDRLG
110 120 130 140 150
GEAALDGEPA VSTYHSYAAR LFGDHALRAA LEPTMRLISP AMAWQLAARV
160 170 180 190 200
VDDYDGAMDG IDWRPDTVVR AVLDLSGELA EHLRTPEDVR EIGRRLRAQF
210 220 230 240 250
DALPGRRGAA KNVLATQEIR ERLLPLVEAY QRAKIEREVL DYGDQVALAA
260 270 280 290 300
RIARDHPDVG MIERSRYAVV LLDEYQDTSH AQLVLLTSLF GGGHPVTAVG
310 320 330 340 350
DPCQSIYGWR GAGSGNLTGF PEDFPLAPAV PSRVAAVPPP RPGRRPPRHA
360 370 380 390 400
RPAPTATLSI SWRNGERILE VAARIQQGLR ADTANVPRLR PGEGRRGRGR
410 420 430 440 450
VECALLPTVT AEAEHIAERI RRLRAADPEL APDGLPWDEG PLKYSHIAVL
460 470 480 490 500
VRRRSQIPPL RKALEERDIP VEVVGLGGLL TVPEVQDVVA TLRVVHDPTA
510 520 530 540 550
GASLARLLTG PRWRIGPRDL VALGRRARRL ASENTRDITP PPDASELRPE
560 570 580 590 600
PAANAEETDP LRQVVIELTQ ETGSLVDALD DLGDPSAYSP EGLARLRRLA
610 620 630 640 650
AELRTLRSQV GLPLPDLVAE VERTLGLDIE VAARSGLDPA GARADLDAFI
660 670 680 690 700
ETAASFAEES ENPTLGAFLA YLKAAESEEF GLPAGRVSES DSVKLLTVHA
710 720 730 740 750
AKGLEWPVVV VPGLCYLPSG SGRPVKGSIF PSPPQQSTRW TDNPRLLPFE
760 770 780 790 800
LRGDYEKGNL PRLNGLTKAD LDRFKDECAD RDLREERRLA YVAVTRASHL
810 820 830 840 850
LIATGHRWGA TARPLHPSPF LEEIRQACET GAGRVVSWAD PPEEGAANPL
860 870 880 890 900
QAEAEPGRWP ATPEGRRYAA IVEGAEMVRD AMVGRIAPWA GDDGLTEADR
910 920 930 940 950
RRMTAWARDV ELLLAERDRG RGGDVLQVEL PAKLTVSTLV ALSRDPQEVA
960 970 980 990 1000
RSIRRPMPRP PAPYARRGTA FHRWLESRWG QQRLLDPDEL PGAADEGAAD
1010 1020 1030 1040 1050
DSMLTELQRR FEESEWASRR PLDIEVTFET VLGDRVLRGR MDAVFTAPDG
1060 1070 1080 1090 1100
GYEVVDWKTG RPPADEDFRH AAVQLAAYRL AWADLAGVPL EKVSAAFHYV
1110 1120
RYNRTIRPAD LLDRAGLTAL LENIRPID
Length:1,128
Mass (Da):123,729
Last modified:January 19, 2010 - v1
Checksum:iB90C8BE20D7DCE7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA Translation: ACY99286.1

Genome annotation databases

EnsemblBacteriaiACY99286; ACY99286; Tcur_3753
KEGGitcu:Tcur_3753

Entry informationi

Entry nameiD1ACM7_THECD
AccessioniPrimary (citable) accession number: D1ACM7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health