D1AAV4 (D1AAV4_THECD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate kinase HAMAP-Rule MF_00451
Short name=NDK HAMAP-Rule MF_00451
Short name=NDP kinase HAMAP-Rule MF_00451
EC=2.7.4.6 HAMAP-Rule MF_00451

Alternative name(s):
Nucleoside-2-P kinase HAMAP-Rule MF_00451

Gene names

Name:	ndk HAMAP-Rule MF_00451
Ordered Locus Names:	Tcur_1538

Organism

Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081) [Complete proteome] [HAMAP] EMBL ACY97114.1

Taxonomic identifier

471852 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Thermomonosporaceae › Thermomonospora › Thermomonospora curvata

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. HAMAP-Rule MF_00451
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_00451 RuleBase RU004013
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00451
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00451
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00451.
Sequence similarities	Belongs to the NDK family. HAMAP-Rule MF_00451 RuleBase RU004011

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP-Rule MF_00451
Cellular component	Cytoplasm HAMAP-Rule MF_00451
Ligand	ATP-binding HAMAP-Rule MF_00451 RuleBase RU004013 Magnesium HAMAP-Rule MF_00451 Metal-binding HAMAP-Rule MF_00451 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00451 RuleBase RU004013 EMBL ACY97114.1 Transferase
PTM	Phosphoprotein HAMAP-Rule MF_00451
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CTP biosynthetic process Inferred from electronic annotation. Source: HAMAP GTP biosynthetic process Inferred from electronic annotation. Source: HAMAP UTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	116	1	Pros-phosphohistidine intermediate By similarity HAMAP-Rule MF_00451
	Binding site	10	1	ATP By similarity HAMAP-Rule MF_00451
	Binding site	58	1	ATP By similarity HAMAP-Rule MF_00451
	Binding site	86	1	ATP By similarity HAMAP-Rule MF_00451
	Binding site	92	1	ATP By similarity HAMAP-Rule MF_00451
	Binding site	103	1	ATP By similarity HAMAP-Rule MF_00451
	Binding site	113	1	ATP By similarity HAMAP-Rule MF_00451

Sequences

	Sequence		Length	Mass (Da)
	D1AAV4 [UniParc]. Last modified January 19, 2010. Version 1. Checksum: 0E961E3887FCAC78	FASTA	136	14,818
	10 20 30 40 50 60 MSERTLVLVK PDGVRRGVVG DVISRIERKG LKIIAMEMRT LSRETAEDHY GEHRERPFFG 70 80 90 100 110 120 ELVDFITGGP LVAMVVEGPR AIEAFRALAG ATDPVKAAPG TIRGDHALEI GENIVHGSDS 130 PESAAREIKL FFPELA

References

[1]

"Complete genome sequence of Thermomonospora curvata type strain (B9)." Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Glavina Del Rio T., Tice H., Cheng J., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A., Palaniappan K. , Djao O., Land M., Hauser L., Chang Y., Jeffries C., Brettin T., Han C., Detter J., Rohde M., Goker M., Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P., Klenk H., Kyrpides N. Stand. Genomic Sci. 1:13-22(2011) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001738 Genomic DNA. Translation: ACY97114.1.
RefSeq	YP_003299152.1. NC_013510.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACY97114; ACY97114; Tcur_1538.
GeneID	8602854.
KEGG	tcu:Tcur_1538.
PATRIC	32512655. VBITheCur33965_1567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000224565.
KO	K00940.
OMA	FRVVAMK.
Family and domain databases
Gene3D	3.30.70.141. 1 hit.
HAMAP	MF_00451. NDP_kinase.
InterPro	IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view]
PANTHER	PTHR11349. PTHR11349. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
SUPFAM	SSF54919. NDK. 1 hit.
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D1AAV4_THECD

Accession

Primary (citable) accession number: D1AAV4

Entry history

Integrated into UniProtKB/TrEMBL:	January 19, 2010
Last sequence update:	January 19, 2010
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)