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D1A961 (D1A961_THECD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Tcur_4976 EMBL ACZ00491.1
OrganismThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081) [Complete proteome] [HAMAP] EMBL ACZ00491.1
Taxonomic identifier471852 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeThermomonospora

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain108 – 315208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding142 – 19756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2691Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D1A961 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: CB9E9520A01D0E37

FASTA31933,624
        10         20         30         40         50         60 
MADLNVPELG HVIVLAGGLS YEREVSLRSG RRVADALRAL DVDAQVHDAD ATLLQTLQQA 

        70         80         90        100        110        120 
PPDAVFPVLH GSMGEDGAIR DVLELVGVPY VGARPDACRV AWDKPTAKSV VRAAGLATPP 

       130        140        150        160        170        180 
SVTLPKEVFH DLGAAAVLEC VVRRLGLPLF VKPARGGSAL GASVVREAGD LPAAMVGCFA 

       190        200        210        220        230        240 
YGDAALIERH IEGTEVAVSV IERDGEPVAL PAVEIVPAGE LYDYTARYDA GDTEFVTPAR 

       250        260        270        280        290        300 
LPEEVARRAA EAAVTAHRAL GLRDLSRTDL IVDEAGQVHF LEVNVAPGMT ETSLFPRAVA 

       310 
AAGLNLGRIL HDLIVARLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001738 Genomic DNA. Translation: ACZ00491.1.
RefSeqYP_003302528.1. NC_013510.1.

3D structure databases

ProteinModelPortalD1A961.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ00491; ACZ00491; Tcur_4976.
GeneID8606342.
KEGGtcu:Tcur_4976.
PATRIC32519708. VBITheCur33965_5054.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMAINSISPC.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycTCUR471852:GHHD-5052-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1A961_THECD
AccessionPrimary (citable) accession number: D1A961
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)