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D1A3V2

- PSB2_THECD

UniProt

D1A3V2 - PSB2_THECD

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Protein

Proteasome subunit beta 2

Gene

prcB2

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531NucleophileUniRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-2489-MONOMER.
UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 2UniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunit 2UniRule annotation
Proteasome core protein PrcB 2UniRule annotation
Gene namesi
Name:prcB2UniRule annotation
Ordered Locus Names:Tcur_2442
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeThermomonospora
ProteomesiUP000001918: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 5252Removed in mature form; by autocatalysisUniRule annotationPRO_0000397598Add
BLAST
Chaini53 – 280228Proteasome subunit beta 2PRO_0000397599Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245308.
KOiK03433.
OMAiNNVDLFH.
OrthoDBiEOG6ND0PJ.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_B. Proteasome_B_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D1A3V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTERERGQGL PAEFFAVGTA SFVELLSRTA PQLLPVNRVR DGSHPMPDIP
60 70 80 90 100
HGTTIVAVRY PEGVMLAGDR RATSGNLIAQ KDLEKVHRAD EHSAVAMAGT
110 120 130 140 150
VGLALEMIRL LQVELEHYEK LQSAKLSLPG KARRLGAVIR ANLAHAMQGL
160 170 180 190 200
AVVPVFAGYD LDAGVGRIYN YDITGMPQES RDFHAEGSGS PFARGALKKL
210 220 230 240 250
YRPDLTEAEA AAVCVQALYD AAEDDAATAG PDLARRIFPT IATVTADGYR
260 270 280
RLPEQEVAEL TESVVGARRQ RPDGPVAPLR
Length:280
Mass (Da):30,170
Last modified:January 19, 2010 - v1
Checksum:iACCF168140F579B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001738 Genomic DNA. Translation: ACY98005.1.
RefSeqiWP_012852789.1. NC_013510.1.
YP_003300043.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY98005; ACY98005; Tcur_2442.
GeneIDi8603779.
KEGGitcu:Tcur_2442.
PATRICi32514556. VBITheCur33965_2496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001738 Genomic DNA. Translation: ACY98005.1 .
RefSeqi WP_012852789.1. NC_013510.1.
YP_003300043.1. NC_013510.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY98005 ; ACY98005 ; Tcur_2442 .
GeneIDi 8603779.
KEGGi tcu:Tcur_2442.
PATRICi 32514556. VBITheCur33965_2496.

Phylogenomic databases

HOGENOMi HOG000245308.
KOi K03433.
OMAi NNVDLFH.
OrthoDBi EOG6ND0PJ.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci TCUR471852:GHHD-2489-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_B. Proteasome_B_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081.

Entry informationi

Entry nameiPSB2_THECD
AccessioniPrimary (citable) accession number: D1A3V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 19, 2010
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3