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Protein

Alanine racemase

Gene

Tcur_4267

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Tcur_4267)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Active sitei264Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei312Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-4251-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Tcur_4267Imported
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)Imported
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesThermomonosporaceaeThermomonospora
Proteomesi
  • UP000001918 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi471852.Tcur_4267.

Structurei

3D structure databases

ProteinModelPortaliD1A324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 370Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D1A324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREPVQARVD LDAIRANVAL LRERAGGAET MAMVKAEGYG HGLVEAARAA
60 70 80 90 100
LEGGAGWLGV ARVAEALRLR AAGITVPVLV VMATRGEPFE EAVAAGVDLT
110 120 130 140 150
AGSGWQARRL AEAAERAGRP ARVHLKADTG MSRGGATMAD WPATVEAALA
160 170 180 190 200
AQAAGHLRVV GVMSHLACAD EPGHPSIARQ LAVFKEAVEY AEKAGVRPQV
210 220 230 240 250
RHLSNSAATL TLPEARYDLV RPGIAIYGLT PVPQMGTFGL RPAMTLVAEL
260 270 280 290 300
AAVKRVPAGS GVSYGHTYVT ERETTLGLVA AGYGDGVPRH GSSLLEVLAG
310 320 330 340 350
GRRRRIAGRV CMDQFVIDLG DDTASPGEEV LLFGPGDHGE PTAQEWAQAL
360 370
GTISYEIVTR IGTRVPRVYS GARWQ
Length:375
Mass (Da):39,355
Last modified:January 19, 2010 - v1
Checksum:i94E4B931C926E1E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY99794.1.
RefSeqiWP_012854577.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY99794; ACY99794; Tcur_4267.
KEGGitcu:Tcur_4267.

Similar proteinsi

Entry informationi

Entry nameiD1A324_THECD
AccessioniPrimary (citable) accession number: D1A324
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: September 27, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported