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Protein

Proteasome subunit alpha

Gene

prcA

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi: proteasomal Pup-dependent pathway

This protein is involved in the pathway proteasomal Pup-dependent pathway, which is part of Protein degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway proteasomal Pup-dependent pathway and in Protein degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

UniPathwayiUPA00997.

Protein family/group databases

MEROPSiT01.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PrcAUniRule annotation
Gene namesi
Name:prcAUniRule annotation
Ordered Locus Names:Tcur_2312
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NBRC 15933 / NCIMB 10081 / Henssen B9)
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesThermomonosporaceaeThermomonospora
Proteomesi
  • UP000001918 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003971811 – 230Proteasome subunit alphaAdd BLAST230

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Protein-protein interaction databases

STRINGi471852.Tcur_2312.

Structurei

3D structure databases

SMRiD1A2T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F7N. Bacteria.
COG0638. LUCA.
HOGENOMiHOG000245319.
KOiK03432.
OrthoDBiPOG091H08XR.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR022296. Proteasome_asu_bac.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF69. PTHR11599:SF69. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D1A2T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMPFYVPAE QQMKDKADYA RKGIARGRSV VVLQYDDGIL FVADNPSRAL
60 70 80 90 100
HKISEIYDRI AFAAVGKYNE FETLRLAGVR YADINGYQYD RRDVTARGLA
110 120 130 140 150
NAYAQTLGTI FTETAKPYEV ELVVAEAGLD ADSDQIYRLT FDGSVRDEHG
160 170 180 190 200
YVAMGGQVDA VEQALKERFT EGMSLSAALR AGVQSLEAQE SGRRLEAKAL
210 220 230
EVAVLDRNRE HRLFRRLPAP RIEELLAEGA
Length:230
Mass (Da):25,658
Last modified:August 10, 2010 - v2
Checksum:i8CEADDCC1EAE5614
GO

Sequence cautioni

The sequence ACY97878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY97878.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiACY97878; ACY97878; Tcur_2312.
KEGGitcu:Tcur_2312.

Similar proteinsi

Entry informationi

Entry nameiPSA_THECD
AccessioniPrimary (citable) accession number: D1A2T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 22, 2017
This is version 55 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families