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D1A2T0

- PSA_THECD

UniProt

D1A2T0 - PSA_THECD

Protein

Proteasome subunit alpha

Gene

prcA

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 2 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.UniRule annotation

    Enzyme regulationi

    The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    BioCyciTCUR471852:GHHD-2359-MONOMER.
    UniPathwayiUPA00997.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
    Alternative name(s):
    20S proteasome alpha subunitUniRule annotation
    Proteasome core protein PrcAUniRule annotation
    Gene namesi
    Name:prcAUniRule annotation
    Ordered Locus Names:Tcur_2312
    OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
    Taxonomic identifieri471852 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeThermomonospora
    ProteomesiUP000001918: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Proteasome subunit alphaPRO_0000397181Add
    BLAST

    Interactioni

    Subunit structurei

    The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000245319.
    KOiK03432.
    OrthoDBiEOG6NKQZG.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00289_B. Proteasome_A_B.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR022296. Proteasome_asu_bac.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
    PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1A2T0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMPFYVPAE QQMKDKADYA RKGIARGRSV VVLQYDDGIL FVADNPSRAL    50
    HKISEIYDRI AFAAVGKYNE FETLRLAGVR YADINGYQYD RRDVTARGLA 100
    NAYAQTLGTI FTETAKPYEV ELVVAEAGLD ADSDQIYRLT FDGSVRDEHG 150
    YVAMGGQVDA VEQALKERFT EGMSLSAALR AGVQSLEAQE SGRRLEAKAL 200
    EVAVLDRNRE HRLFRRLPAP RIEELLAEGA 230
    Length:230
    Mass (Da):25,658
    Last modified:August 10, 2010 - v2
    Checksum:i8CEADDCC1EAE5614
    GO

    Sequence cautioni

    The sequence ACY97878.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001738 Genomic DNA. Translation: ACY97878.1. Different initiation.
    RefSeqiYP_003299916.1. NC_013510.1.

    Genome annotation databases

    EnsemblBacteriaiACY97878; ACY97878; Tcur_2312.
    GeneIDi8603649.
    KEGGitcu:Tcur_2312.
    PATRICi32514292. VBITheCur33965_2365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001738 Genomic DNA. Translation: ACY97878.1 . Different initiation.
    RefSeqi YP_003299916.1. NC_013510.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY97878 ; ACY97878 ; Tcur_2312 .
    GeneIDi 8603649.
    KEGGi tcu:Tcur_2312.
    PATRICi 32514292. VBITheCur33965_2365.

    Phylogenomic databases

    HOGENOMi HOG000245319.
    KOi K03432.
    OrthoDBi EOG6NKQZG.

    Enzyme and pathway databases

    UniPathwayi UPA00997 .
    BioCyci TCUR471852:GHHD-2359-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00289_B. Proteasome_A_B.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR022296. Proteasome_asu_bac.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR03691. 20S_bact_alpha. 1 hit.
    PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081.

    Entry informationi

    Entry nameiPSA_THECD
    AccessioniPrimary (citable) accession number: D1A2T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3