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D1A2S9

- PSB1_THECD

UniProt

D1A2S9 - PSB1_THECD

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Protein
Proteasome subunit beta 1
Gene
prcB1, Tcur_2311
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
  2. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-2358-MONOMER.
UniPathwayiUPA00997.

Protein family/group databases

MEROPSiT01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 1 (EC:3.4.25.1)
Alternative name(s):
20S proteasome beta subunit 1
Proteasome core protein PrcB 1
Gene namesi
Name:prcB1
Ordered Locus Names:Tcur_2311
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeThermomonospora
ProteomesiUP000001918: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 5656Removed in mature form; by autocatalysis By similarity
PRO_0000397596Add
BLAST
Chaini57 – 284228Proteasome subunit beta 1UniRule annotation
PRO_0000397597Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

HOGENOMiHOG000245308.
KOiK03433.
OMAiFQVELEH.
OrthoDBiEOG6XM79W.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_B. Proteasome_B_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D1A2S9-1 [UniParc]FASTAAdd to Basket

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MASHDSYTGR LPGAFMNPGT SSFTEFLASY NPDLLPGRHM TALAGGMPGN    50
VEAPHATTIV AVTFPGGVVM AGDRRATAGN MIAQRDVEKV FRADEFSAVA 100
IAGTAGIGME IVRLFQVEIE HYEKMEGRTL SLEGKANRLA TMIRANLGMA 150
MQGLVAVPLF AGYDTEREVG RIFSYDPAGG RYEEHEHHSI GSGSVFARGA 200
LKKLWRPDLS AQDAALVCVQ ALYDAADDDS ATGGPDLIRK IYPVVATVTA 250
DGFRRLPEEE VGELARIVVD GRHDSPGGPT APLR 284
Length:284
Mass (Da):30,317
Last modified:January 19, 2010 - v1
Checksum:i8F0B5BD4B7311B59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001738 Genomic DNA. Translation: ACY97877.1.
RefSeqiYP_003299915.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY97877; ACY97877; Tcur_2311.
GeneIDi8603648.
KEGGitcu:Tcur_2311.
PATRICi32514290. VBITheCur33965_2364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001738 Genomic DNA. Translation: ACY97877.1 .
RefSeqi YP_003299915.1. NC_013510.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY97877 ; ACY97877 ; Tcur_2311 .
GeneIDi 8603648.
KEGGi tcu:Tcur_2311.
PATRICi 32514290. VBITheCur33965_2364.

Phylogenomic databases

HOGENOMi HOG000245308.
KOi K03433.
OMAi FQVELEH.
OrthoDBi EOG6XM79W.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci TCUR471852:GHHD-2358-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_B. Proteasome_B_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022483. Pept_T1A_Psome_suB_actinobac.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081.

Entry informationi

Entry nameiPSB1_THECD
AccessioniPrimary (citable) accession number: D1A2S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi