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Protein

Proteasome-associated ATPase

Gene

arc

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.UniRule annotation

Pathwayi: proteasomal Pup-dependent pathway

This protein is involved in the pathway proteasomal Pup-dependent pathway, which is part of Protein degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway proteasomal Pup-dependent pathway and in Protein degradation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-2354-MONOMER.
UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome-associated ATPaseUniRule annotation
Alternative name(s):
AAA ATPase forming ring-shaped complexesUniRule annotation
Short name:
ARCUniRule annotation
Proteasomal ATPaseUniRule annotation
Gene namesi
Name:arcUniRule annotation
Ordered Locus Names:Tcur_2307
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesThermomonosporaceaeThermomonospora
Proteomesi
  • UP000001918 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Proteasome-associated ATPasePRO_0000397028Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Assembles into a hexameric ring structure that caps the 20S proteasome core. Strongly interacts with the prokaryotic ubiquitin-like protein Pup through a hydrophobic interface; the interacting region of ARC lies in its N-terminal coiled-coil domain. There is one Pup binding site per ARC hexamer ring. Upon ATP-binding, the C-terminus of ARC interacts with the alpha-rings of the proteasome core, possibly by binding to the intersubunit pockets.UniRule annotation

Protein-protein interaction databases

STRINGi471852.Tcur_2307.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni586 – 5872Docks into pockets in the proteasome alpha-ringUniRule annotation

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili9 – 9486UniRule annotationAdd
BLAST

Domaini

Consists of three main regions, an N-terminal coiled-coil domain that binds to protein Pup and functions as a docking station, an interdomain involved in ARC hexamerization, and a C-terminal ATPase domain of the AAA type.UniRule annotation

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105DHM. Bacteria.
COG0464. LUCA.
HOGENOMiHOG000245286.
KOiK13527.
OMAiCVDEFKE.
OrthoDBiEOG6MH5BZ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02112. ARC_ATPase.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR032501. Prot_ATP_ID_OB.
IPR022482. Proteasome_ATPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16450. Prot_ATP_ID_OB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03689. pup_AAA. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1A2S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARDDAGAR KAQHDAEIHD LRSQVSMLEE EVSVLRRKLA ESPRQIRVLE
60 70 80 90 100
DRLHETQAKL AAVTGQNERL VATLKEAREQ IIALKEEVDR LAQPPSGFGV
110 120 130 140 150
FLGAREDGTV DIFTGGRKLR VNVSPSVDVS QLKQGQEVLL NEALNVVEAL
160 170 180 190 200
GYETQGEVVM LKELFDDGER ALVIAHADEE RVIKLAEPLR GVPLRAGDSL
210 220 230 240 250
MLEPRSGYAY EKIHKAEVEE LVLEEVPDIT YEEIGGLGPQ IEQIRDAVEL
260 270 280 290 300
PYLHADLFRE HKLRPPKGVL LYGPPGCGKT LIAKAVANSL AKQVAEKTGQ
310 320 330 340 350
EGKSFFLNIK GPELLNKYVG ETERHIRLVF QRAREKASAG TPVIVFFDEM
360 370 380 390 400
DSIFRTRGSG VSSDVENTIV PQLLSEIDGV EGLENVIVIG ASNREDMIDP
410 420 430 440 450
AILRPGRLDV KIKIERPDAE AAKDIFSKYL VPGLPLHPDD LAEHGGSEEA
460 470 480 490 500
TIEAMIQRVV ERMYAETEEN RFLEVTYANG DKEVLYFKDF NSGAMIQNIV
510 520 530 540 550
DRAKKMAIKQ YLETGQKGLR VSHLLAACVD EFSENEDLPN TTNPDDWARI
560 570 580
SGKKGERIVY IRTLVSGKAG SEAGRSIDTV ANTGQYL
Length:587
Mass (Da):65,001
Last modified:January 19, 2010 - v1
Checksum:iE5DAF8ACB9121D43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY97873.1.
RefSeqiWP_012852657.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY97873; ACY97873; Tcur_2307.
KEGGitcu:Tcur_2307.
PATRICi32514280. VBITheCur33965_2359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY97873.1.
RefSeqiWP_012852657.1. NC_013510.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471852.Tcur_2307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY97873; ACY97873; Tcur_2307.
KEGGitcu:Tcur_2307.
PATRICi32514280. VBITheCur33965_2359.

Phylogenomic databases

eggNOGiENOG4105DHM. Bacteria.
COG0464. LUCA.
HOGENOMiHOG000245286.
KOiK13527.
OMAiCVDEFKE.
OrthoDBiEOG6MH5BZ.

Enzyme and pathway databases

UniPathwayiUPA00997.
BioCyciTCUR471852:GHHD-2354-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02112. ARC_ATPase.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR032501. Prot_ATP_ID_OB.
IPR022482. Proteasome_ATPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16450. Prot_ATP_ID_OB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03689. pup_AAA. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081.

Entry informationi

Entry nameiARC_THECD
AccessioniPrimary (citable) accession number: D1A2S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 19, 2010
Last modified: July 6, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.