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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561UniRule annotation
Active sitei552 – 5521UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-4195-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Tcur_4129Imported
OrganismiThermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)Imported
Taxonomic identifieri471852 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeThermomonosporaceaeThermomonospora
ProteomesiUP000001918 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1A204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDSAAGQVP SEQRKALREE MPEPLRRDVR LLGAMLGEIL VEYGGPDLLE
60 70 80 90 100
DVERLRHAVI DARQGRVSID EAAALVAGWD LERAELVARA FTVYFHLTNL
110 120 130 140 150
AEEHHRIRAL RERDTDPAHP VSGSLAAAVA QIRGTGEHRL AQVLDGLEFR
160 170 180 190 200
PVFTAHPTEA RRRAVVTAIM RISALLQDFN DPRKGAAERD EIRRQLREEI
210 220 230 240 250
DLLWRTALRR HTQMDPLDEV RTAMAAFDET IFRVVPQLYR ALDSALDVGA
260 270 280 290 300
SGPASGARPP RAHAYLRFGS WIGGDRDGNP YVTAQITREA VLIQSDHVLR
310 320 330 340 350
ALENACTRIG RRLTVSSATT PPSAALRNAL DAARTAYPLL IAELAKRSPE
360 370 380 390 400
EPHRQYLLYV AERIAATRAR HADMAYRSPE ELLADLRLVQ ESLAGAGAVR
410 420 430 440 450
QAYGELQHLI WQTETFGFHL AELEIRQHSQ VHEKALAEVR AGGALSEMTE
460 470 480 490 500
EVLDTLRVVS WIQRRFGVRA CHRYVVSFTR SADDIAAVYE LAESLGDHAP
510 520 530 540 550
VLDVVPLFET GEDLDRAPSV LEGMLKLPAV QRRLAETGRR LEVMLGYSDS
560 570 580 590 600
AKQLGPTSAT LRLYDAQAAL AAWAARNGIT LTLFHGRGGS LGRGGGPANR
610 620 630 640 650
AILAQAPGSV NGRFKVTEQG EVIFARYGQR EIAKRHIEQV TNAIMLASTP
660 670 680 690 700
AVEARAHEAA VRFRPLADRI SAAAQAAFRA LIETEGFAEW FARVSPLEEI
710 720 730 740 750
SRLRIGSRPA RRTATRSLED LRAIPWVFAW TQTRVNLPGW YGLGSGLEAV
760 770 780 790 800
LGGGDDEAGL AELQEAYRSW PLFAVMLDNA EMSLAKADRA IAERYLALGG
810 820 830 840 850
RPELTERVLA EYDRTRSLVL AVTGHRRLLE NRRVLSRAVE LRNPYVDALS
860 870 880 890
LLQLRALTAL REGVADDAER ARLEELLLLS VNGVAAGLQN TG
Length:892
Mass (Da):98,526
Last modified:January 18, 2010 - v1
Checksum:i1B830F81F9ADB7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY99657.1.
RefSeqiYP_003301695.1. NC_013510.1.

Genome annotation databases

EnsemblBacteriaiACY99657; ACY99657; Tcur_4129.
KEGGitcu:Tcur_4129.
PATRICi32518014. VBITheCur33965_4214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001738 Genomic DNA. Translation: ACY99657.1.
RefSeqiYP_003301695.1. NC_013510.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY99657; ACY99657; Tcur_4129.
KEGGitcu:Tcur_4129.
PATRICi32518014. VBITheCur33965_4214.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciTCUR471852:GHHD-4195-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081Imported.

Entry informationi

Entry nameiD1A204_THECD
AccessioniPrimary (citable) accession number: D1A204
Entry historyi
Integrated into UniProtKB/TrEMBL: January 18, 2010
Last sequence update: January 18, 2010
Last modified: March 31, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.