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D1A039 (D1A039_CHLPP) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387
Gene names
Name:lpxA HAMAP MF_00387 EMBL ACZ32534.1
Ordered Locus Names:CPK_ORF00050
OrganismChlamydophila pneumoniae (strain LPCoLN) [Complete proteome] [HAMAP]
Taxonomic identifier406984 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387 SAAS SAAS010137

Catalytic activity

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387 SAAS SAAS010137

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387 SAAS SAAS010137

Subunit structure

Homotrimer By similarity. HAMAP MF_00387 SAAS SAAS010137

Subcellular location

Cytoplasm By similarity HAMAP MF_00387.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Sequences

Sequence LengthMass (Da)Tools
D1A039 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 113FED5145F93BA8

FASTA28330,847
        10         20         30         40         50         60 
MASIHPTAII EPGAKIGKDV VIEPYVVIKA TVTLCDNVVV KSYAYIDGNT TIGKGTTIWP 

        70         80         90        100        110        120 
SAMIGNKPQD LKYQGEKTYV TIGENCEIRE FAIITSSTFE GTTVSIGNNC LIMPWAHVAH 

       130        140        150        160        170        180 
NCTIGNNVVL SNHAQLAGHV QVGDYAILGG MVGVHQFVRI GAHAMVGALS GIRRDVPPYT 

       190        200        210        220        230        240 
IGSGNPYQLA GINKVGLQRR QVPFTTRLAL IKAFKKIYRA DGCFFESLEE TLEETLEEYG 

       250        260        270        280 
DIPEVKNFIE FCQSPSKRGI ERSIDKQALE EESADKEGVL IES

« Hide

References

[1]"Evidence that human Chlamydia pneumoniae was zoonotically acquired."
Myers G.S., Mathews S.A., Eppinger M., Mitchell C., O'Brien K.K., White O.R., Benahmed F., Brunham R.C., Read T.D., Ravel J., Bavoil P.M., Timms P.
J. Bacteriol. 191:7225-7233(2009) [PubMed: 19749045] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001713 Genomic DNA. Translation: ACZ32534.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus CPK_ORF00050 in contig CP001713_GR.
PATRIC36821334. VBIChlPne19997_0102.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAREFCTFN.

Family and domain databases

HAMAPMF_00387. LpxA.
[Tree]
InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_lpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF00132. Hexapep. 4 hits.
[Graphical view]
PIRSFPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMsTIGR01852. Lipid_A_lpxA. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1A039_CHLPP
AccessionPrimary (citable) accession number: D1A039
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: January 25, 2012
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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