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D0ZYX1

- D0ZYX1_CHLPP

UniProt

D0ZYX1 - D0ZYX1_CHLPP

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Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Chlamydophila pneumoniae (strain LPCoLN)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADPUniRule annotation
Active sitei136 – 1361Proton donor/acceptorUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei140 – 1401Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NAD(P)UniRule annotation
Nucleotide bindingi76 – 783NAD(P)UniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCPNE406984:GLB7-814-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotationSAAS annotation (EC:1.17.1.8UniRule annotationSAAS annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotationImported
Ordered Locus Names:CPK_ORF00474Imported
OrganismiChlamydophila pneumoniae (strain LPCoLN)Imported
Taxonomic identifieri406984 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002636: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1472Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227153.
KOiK00215.
OMAiEGCDIEI.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0ZYX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVGVIGCSG RTGKVIVSAL EQSSEYTLGP GFSRSSALTL SQVIAHNDVL
60 70 80 90 100
VDFSHPLLTK EVVAHLLISP KPLIIGTTGF PGKCKEAHDS LEELTHIVPV
110 120 130 140 150
VVCPNASLGA YIHKRLVMLL SQLCNPQFDI RIRETHHRYK KDSLSGTAQD
160 170 180 190 200
LLDTIQQVKQ EDWGEEYEVG QRDSSKKTIE VQSSRVGDIP GEHEVAFISS
210 220 230 240 250
GEQILVRHTV FSRNVFGQGI LSILDWLKTL NPQPGLYSLG DDTLELVLRN
260
EHCLLKKTTD H
Length:261
Mass (Da):28,848
Last modified:January 19, 2010 - v1
Checksum:iE0D85DF40CD8C6C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001713 Genomic DNA. Translation: ACZ32949.1.
RefSeqiWP_014518073.1. NC_017285.1.
YP_005662369.1. NC_017285.1.

Genome annotation databases

EnsemblBacteriaiACZ32949; ACZ32949; CPK_ORF00474.
GeneIDi12243728.
KEGGiclp:CPK_ORF00474.
PATRICi36822805. VBIChlPne19997_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001713 Genomic DNA. Translation: ACZ32949.1 .
RefSeqi WP_014518073.1. NC_017285.1.
YP_005662369.1. NC_017285.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ32949 ; ACZ32949 ; CPK_ORF00474 .
GeneIDi 12243728.
KEGGi clp:CPK_ORF00474.
PATRICi 36822805. VBIChlPne19997_0815.

Phylogenomic databases

HOGENOMi HOG000227153.
KOi K00215.
OMAi EGCDIEI.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci CPNE406984:GLB7-814-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LPCoLNImported.

Entry informationi

Entry nameiD0ZYX1_CHLPP
AccessioniPrimary (citable) accession number: D0ZYX1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3