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D0ZYX1 (D0ZYX1_CHLPP) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-tetrahydrodipicolinate reductase HAMAP-Rule MF_00102
Short name=HTPA reductase HAMAP-Rule MF_00102
EC=1.17.1.- HAMAP-Rule MF_00102
Gene names
Name:dapB HAMAP-Rule MF_00102 EMBL ACZ32949.1
Ordered Locus Names:CPK_ORF00474 EMBL ACZ32949.1
OrganismChlamydophila pneumoniae (strain LPCoLN) [Complete proteome] [HAMAP] EMBL ACZ32949.1
Taxonomic identifier406984 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia ›

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate By similarity. HAMAP-Rule MF_00102 SAAS SAAS023940

Catalytic activity

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. HAMAP-Rule MF_00102 SAAS SAAS023940

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP-Rule MF_00102 SAAS SAAS023940

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00102 SAAS SAAS023940.

Sequence similarities

Belongs to the DapB family. HAMAP-Rule MF_00102

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli (PubMed:20503968) that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. HAMAP-Rule MF_00102

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding7 – 126NAD(P) By similarity HAMAP-Rule MF_00102
Nucleotide binding76 – 783NAD(P) By similarity HAMAP-Rule MF_00102
Region146 – 1472Substrate binding By similarity HAMAP-Rule MF_00102

Sites

Active site1361Proton donor/acceptor By similarity HAMAP-Rule MF_00102
Active site1401Proton donor By similarity HAMAP-Rule MF_00102
Binding site341NADP By similarity HAMAP-Rule MF_00102
Binding site1371Substrate By similarity HAMAP-Rule MF_00102

Sequences

Sequence LengthMass (Da)Tools
D0ZYX1 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: E0D85DF40CD8C6C9

FASTA26128,848
        10         20         30         40         50         60 
MHVGVIGCSG RTGKVIVSAL EQSSEYTLGP GFSRSSALTL SQVIAHNDVL VDFSHPLLTK 

        70         80         90        100        110        120 
EVVAHLLISP KPLIIGTTGF PGKCKEAHDS LEELTHIVPV VVCPNASLGA YIHKRLVMLL 

       130        140        150        160        170        180 
SQLCNPQFDI RIRETHHRYK KDSLSGTAQD LLDTIQQVKQ EDWGEEYEVG QRDSSKKTIE 

       190        200        210        220        230        240 
VQSSRVGDIP GEHEVAFISS GEQILVRHTV FSRNVFGQGI LSILDWLKTL NPQPGLYSLG 

       250        260 
DDTLELVLRN EHCLLKKTTD H

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References

[1]"Evidence that human Chlamydia pneumoniae was zoonotically acquired."
Myers G.S., Mathews S.A., Eppinger M., Mitchell C., O'Brien K.K., White O.R., Benahmed F., Brunham R.C., Read T.D., Ravel J., Bavoil P.M., Timms P.
J. Bacteriol. 191:7225-7233(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LPCoLN EMBL ACZ32949.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001713 Genomic DNA. Translation: ACZ32949.1.
RefSeqYP_005662369.1. NC_017285.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ32949; ACZ32949; CPK_ORF00474.
GeneID12243728.
KEGGclp:CPK_ORF00474.
PATRIC36822805. VBIChlPne19997_0815.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000227153.
KOK00215.
OMAHEVAFIS.

Enzyme and pathway databases

UniPathwayUPA00034; UER00018.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00102. DapB.
InterProIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR20836. PTHR20836. 1 hit.
PfamPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFPIRSF000161. DHPR. 1 hit.
TIGRFAMsTIGR00036. dapB. 1 hit.
PROSITEPS01298. DAPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD0ZYX1_CHLPP
AccessionPrimary (citable) accession number: D0ZYX1
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info