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D0ZYX1

- D0ZYX1_CHLPP

UniProt

D0ZYX1 - D0ZYX1_CHLPP

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Chlamydophila pneumoniae (strain LPCoLN)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADPUniRule annotation
    Active sitei136 – 1361Proton donor/acceptorUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Active sitei140 – 1401Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NAD(P)UniRule annotation
    Nucleotide bindingi76 – 783NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCPNE406984:GLB7-814-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotationImported
    Ordered Locus Names:CPK_ORF00474Imported
    OrganismiChlamydophila pneumoniae (strain LPCoLN)Imported
    Taxonomic identifieri406984 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000002636: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 1472Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000227153.
    KOiK00215.
    OMAiEGCDIEI.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D0ZYX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVGVIGCSG RTGKVIVSAL EQSSEYTLGP GFSRSSALTL SQVIAHNDVL    50
    VDFSHPLLTK EVVAHLLISP KPLIIGTTGF PGKCKEAHDS LEELTHIVPV 100
    VVCPNASLGA YIHKRLVMLL SQLCNPQFDI RIRETHHRYK KDSLSGTAQD 150
    LLDTIQQVKQ EDWGEEYEVG QRDSSKKTIE VQSSRVGDIP GEHEVAFISS 200
    GEQILVRHTV FSRNVFGQGI LSILDWLKTL NPQPGLYSLG DDTLELVLRN 250
    EHCLLKKTTD H 261
    Length:261
    Mass (Da):28,848
    Last modified:January 19, 2010 - v1
    Checksum:iE0D85DF40CD8C6C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001713 Genomic DNA. Translation: ACZ32949.1.
    RefSeqiYP_005662369.1. NC_017285.1.

    Genome annotation databases

    EnsemblBacteriaiACZ32949; ACZ32949; CPK_ORF00474.
    GeneIDi12243728.
    KEGGiclp:CPK_ORF00474.
    PATRICi36822805. VBIChlPne19997_0815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001713 Genomic DNA. Translation: ACZ32949.1 .
    RefSeqi YP_005662369.1. NC_017285.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ32949 ; ACZ32949 ; CPK_ORF00474 .
    GeneIDi 12243728.
    KEGGi clp:CPK_ORF00474.
    PATRICi 36822805. VBIChlPne19997_0815.

    Phylogenomic databases

    HOGENOMi HOG000227153.
    KOi K00215.
    OMAi EGCDIEI.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci CPNE406984:GLB7-814-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LPCoLNImported.

    Entry informationi

    Entry nameiD0ZYX1_CHLPP
    AccessioniPrimary (citable) accession number: D0ZYX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3