D0ZYN7 (D0ZYN7_CHLPP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116

Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116

Gene names

Name:	dut HAMAP MF_00116 EMBL ACZ33033.1
Ordered Locus Names:	CPK_ORF00563

Organism

Chlamydophila pneumoniae (strain LPCoLN) [Complete proteome] [HAMAP]

Taxonomic identifier

406984 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181
Cofactor	Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116
Sequence similarities	Belongs to the dUTPase family. HAMAP MF_00116

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00116 SAAS SAAS008181
Ligand	Magnesium HAMAP MF_00116 SAAS SAAS008181 Metal-binding HAMAP MF_00116 SAAS SAAS008181
Molecular function	Hydrolase HAMAP MF_00116 SAAS SAAS008181 EMBL ACZ33033.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	63 – 65	3	Substrate binding By similarity HAMAP MF_00116
	Region	80 – 82	3	Substrate binding By similarity HAMAP MF_00116
Sites
	Binding site	76	1	Substrate By similarity HAMAP MF_00116

Sequences

	Sequence		Length	Mass (Da)
	D0ZYN7 [UniParc]. Last modified January 19, 2010. Version 1. Checksum: 025E5B34DF488A83	FASTA	145	15,347
	10 20 30 40 50 60 MTVFCELDSG GELPEYTTPG AAGADLRANI EEPIALLPGQ RALIPTGIKA EIPEGYELQV 70 80 90 100 110 120 RPRSGLALKH GITVLNSPGT IDSDYRGEIR VILINFGDST FIIEPKMRIA QVVLSPVVQA 130 140 TFVVKQESLA ETARGSGGFG HTGAS

References

[1]

"Evidence that human Chlamydia pneumoniae was zoonotically acquired." Myers G.S., Mathews S.A., Eppinger M., Mitchell C., O'Brien K.K., White O.R., Benahmed F., Brunham R.C., Read T.D., Ravel J., Bavoil P.M., Timms P. J. Bacteriol. 191:7225-7233(2009) [PubMed: 19749045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001713 Genomic DNA. Translation: ACZ33033.1.
3D structure databases
ProteinModelPortal	D0ZYN7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus CPK_ORF00563 in contig CP001713_GR.
PATRIC	36822621. VBIChlPne19997_0724.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LDLRACI.
Family and domain databases
HAMAP	MF_00116. dUTPase_bact. [Tree]
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D0ZYN7_CHLPP

Accession

Primary (citable) accession number: D0ZYN7

Entry history

Integrated into UniProtKB/TrEMBL:	January 19, 2010
Last sequence update:	January 19, 2010
Last modified:	January 25, 2012
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)