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D0ZJ51

- D0ZJ51_SALT1

UniProt

D0ZJ51 - D0ZJ51_SALT1

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Protein
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Gene
ipk, ispE, STM14_2150
Organism
Salmonella typhimurium (strain 14028s / SGSC 2262)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101 By similarityUniRule annotation
Active sitei141 – 1411 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 10911ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT588858:GJDZ-2151-MONOMER.
UniPathwayiUPA00056; UER00094.

Names & Taxonomyi

Protein namesi
Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
Short name:
CMKUniRule annotation
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene namesi
Name:ipkImported
Synonyms:ispEUniRule annotation
Ordered Locus Names:STM14_2150Imported
OrganismiSalmonella typhimurium (strain 14028s / SGSC 2262)Imported
Taxonomic identifieri588858 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002695: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiD0ZJ51.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0ZJ51.
SMRiD0ZJ51. Positions 1-283.

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.

Sequencei

Sequence statusi: Complete.

D0ZJ51-1 [UniParc]FASTAAdd to Basket

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MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE    50
IHLLTPVNGV ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM 100
GGGLGGGSSN AATVLVALNH LWQCGLSIDE LATLGLTLGA DVPVFVRGHA 150
AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP TPVIFKDPQL PRNTPKRSID 200
TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT GACVFAEFDT 250
ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL 283
Length:283
Mass (Da):30,883
Last modified:January 19, 2010 - v1
Checksum:iE33EAF956D12A5BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001363 Genomic DNA. Translation: ACY88613.1.
RefSeqiYP_005237709.1. NC_016856.1.

Genome annotation databases

EnsemblBacteriaiACY88613; ACY88613; STM14_2150.
PATRICi36735108. VBISalEnt101322_2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001363 Genomic DNA. Translation: ACY88613.1 .
RefSeqi YP_005237709.1. NC_016856.1.

3D structure databases

ProteinModelPortali D0ZJ51.
SMRi D0ZJ51. Positions 1-283.
ModBasei Search...

Proteomic databases

PRIDEi D0ZJ51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY88613 ; ACY88613 ; STM14_2150 .
PATRICi 36735108. VBISalEnt101322_2022.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00094 .
BioCyci SENT588858:GJDZ-2151-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00061. IspE.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF010376. IspE. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00154. ispE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome."
    Jarvik T., Smillie C., Groisman E.A., Ochman H.
    J. Bacteriol. 192:560-567(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 14028s / SGSC 2262.

Entry informationi

Entry nameiD0ZJ51_SALT1
AccessioniPrimary (citable) accession number: D0ZJ51
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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