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D0ZJ51

- D0ZJ51_SALT1

UniProt

D0ZJ51 - D0ZJ51_SALT1

Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ipk

Organism
Salmonella typhimurium (strain 14028s / SGSC 2262)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101UniRule annotation
    Active sitei141 – 1411UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi99 – 10911ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT588858:GJDZ-2151-MONOMER.
    UniPathwayiUPA00056; UER00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
    Short name:
    CMKUniRule annotation
    Alternative name(s):
    4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
    Gene namesi
    Name:ipkImported
    Synonyms:ispEUniRule annotation
    Ordered Locus Names:STM14_2150Imported
    OrganismiSalmonella typhimurium (strain 14028s / SGSC 2262)Imported
    Taxonomic identifieri588858 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000002695: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiD0ZJ51.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD0ZJ51.
    SMRiD0ZJ51. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00061. IspE.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010376. IspE. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00154. ispE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D0ZJ51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE    50
    IHLLTPVNGV ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM 100
    GGGLGGGSSN AATVLVALNH LWQCGLSIDE LATLGLTLGA DVPVFVRGHA 150
    AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP TPVIFKDPQL PRNTPKRSID 200
    TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT GACVFAEFDT 250
    ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL 283
    Length:283
    Mass (Da):30,883
    Last modified:January 19, 2010 - v1
    Checksum:iE33EAF956D12A5BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001363 Genomic DNA. Translation: ACY88613.1.
    RefSeqiYP_005237709.1. NC_016856.1.

    Genome annotation databases

    EnsemblBacteriaiACY88613; ACY88613; STM14_2150.
    PATRICi36735108. VBISalEnt101322_2022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001363 Genomic DNA. Translation: ACY88613.1 .
    RefSeqi YP_005237709.1. NC_016856.1.

    3D structure databases

    ProteinModelPortali D0ZJ51.
    SMRi D0ZJ51. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D0ZJ51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACY88613 ; ACY88613 ; STM14_2150 .
    PATRICi 36735108. VBISalEnt101322_2022.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00094 .
    BioCyci SENT588858:GJDZ-2151-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00061. IspE.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010376. IspE. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00154. ispE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome."
      Jarvik T., Smillie C., Groisman E.A., Ochman H.
      J. Bacteriol. 192:560-567(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 14028s / SGSC 2262Imported.

    Entry informationi

    Entry nameiD0ZJ51_SALT1
    AccessioniPrimary (citable) accession number: D0ZJ51
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3