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D0ZJ51 (D0ZJ51_SALT1) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061

Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ipk EMBL ACY88613.1
Synonyms:ispE HAMAP-Rule MF_00061
Ordered Locus Names:STM14_2150 EMBL ACY88613.1
OrganismSalmonella typhimurium (strain 14028s / SGSC 2262) [Complete proteome] [HAMAP] EMBL ACY88613.1
Taxonomic identifier588858 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding99 – 10911ATP By similarity HAMAP-Rule MF_00061

Sites

Active site101 By similarity HAMAP-Rule MF_00061
Active site1411 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
D0ZJ51 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: E33EAF956D12A5BD

FASTA28330,883
        10         20         30         40         50         60 
MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE IHLLTPVNGV 

        70         80         90        100        110        120 
ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM GGGLGGGSSN AATVLVALNH 

       130        140        150        160        170        180 
LWQCGLSIDE LATLGLTLGA DVPVFVRGHA AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP 

       190        200        210        220        230        240 
TPVIFKDPQL PRNTPKRSID TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT 

       250        260        270        280 
GACVFAEFDT ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL 

« Hide

References

[1]"Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome."
Jarvik T., Smillie C., Groisman E.A., Ochman H.
J. Bacteriol. 192:560-567(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 14028s / SGSC 2262.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001363 Genomic DNA. Translation: ACY88613.1.
RefSeqYP_005237709.1. NC_016856.1.

3D structure databases

ProteinModelPortalD0ZJ51.
SMRD0ZJ51. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDED0ZJ51.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACY88613; ACY88613; STM14_2150.
PATRIC36735108. VBISalEnt101322_2022.

Organism-specific databases

CMRSearch...

Enzyme and pathway databases

BioCycSENT588858:GJDZ-2151-MONOMER.
UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD0ZJ51_SALT1
AccessionPrimary (citable) accession number: D0ZJ51
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)