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Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ipk

Organism
Salmonella typhimurium (strain 14028s / SGSC 2262)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101UniRule annotation
Active sitei141 – 1411UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 10911ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT588858:GJDZ-2151-MONOMER.
UniPathwayiUPA00056; UER00094.

Names & Taxonomyi

Protein namesi
Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
Short name:
CMKUniRule annotation
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
Gene namesi
Name:ipkImported
Synonyms:ispEUniRule annotation
Ordered Locus Names:STM14_2150Imported
OrganismiSalmonella typhimurium (strain 14028s / SGSC 2262)Imported
Taxonomic identifieri588858 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002695: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiD0ZJ51.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0ZJ51.
SMRiD0ZJ51. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

Phylogenomic databases

OMAiDGYHYLQ.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.

Sequencei

Sequence statusi: Complete.

D0ZJ51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMTHWPSPAK LNLFLYITGQ RADGYHTLQT LFQFLDYGDT LHIEPRHDGE
60 70 80 90 100
IHLLTPVNGV ENEDNLIVRA ARLLMKVASE SGRLPAGSGA DISIEKRLPM
110 120 130 140 150
GGGLGGGSSN AATVLVALNH LWQCGLSIDE LATLGLTLGA DVPVFVRGHA
160 170 180 190 200
AFAEGVGEIL TPVNPPEKWY LVAHPGVSIP TPVIFKDPQL PRNTPKRSID
210 220 230 240 250
TLLKCEFSND CEVIARKRFR EVDAALSWLL EYAPSRLTGT GACVFAEFDT
260 270 280
ESCARQVLEQ APEWLNAFVA KGVNLSPLHR ELL
Length:283
Mass (Da):30,883
Last modified:January 19, 2010 - v1
Checksum:iE33EAF956D12A5BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001363 Genomic DNA. Translation: ACY88613.1.
RefSeqiYP_005237709.1. NC_016856.1.

Genome annotation databases

EnsemblBacteriaiACY88613; ACY88613; STM14_2150.
PATRICi36735108. VBISalEnt101322_2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001363 Genomic DNA. Translation: ACY88613.1.
RefSeqiYP_005237709.1. NC_016856.1.

3D structure databases

ProteinModelPortaliD0ZJ51.
SMRiD0ZJ51. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD0ZJ51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY88613; ACY88613; STM14_2150.
PATRICi36735108. VBISalEnt101322_2022.

Phylogenomic databases

OMAiDGYHYLQ.

Enzyme and pathway databases

UniPathwayiUPA00056; UER00094.
BioCyciSENT588858:GJDZ-2151-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome."
    Jarvik T., Smillie C., Groisman E.A., Ochman H.
    J. Bacteriol. 192:560-567(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 14028s / SGSC 2262Imported.

Entry informationi

Entry nameiD0ZJ51_SALT1
AccessioniPrimary (citable) accession number: D0ZJ51
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.