D0ZE09 (TDCC_EDWTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Threonine/serine transporter TdcC

Alternative name(s):
H(+)/threonine-serine symporter

Gene names

Name:	tdcC
Ordered Locus Names:	ETAE_0895

Organism

Edwardsiella tarda (strain EIB202) [Complete proteome] [HAMAP]

Taxonomic identifier

498217 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Edwardsiella › Edwardsiella tarda

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) By similarity. HAMAP-Rule MF_01583
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01583.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
Sequence caution	The sequence ACY83740.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Amino-acid transport Symport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	amino acid transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine transmembrane transporter activity Inferred from electronic annotation. Source: InterPro symporter activity Inferred from electronic annotation. Source: HAMAP threonine efflux transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Threonine/serine transporter TdcC HAMAP-Rule MF_01583		PRO_0000401181
Regions
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Transmembrane	319 – 339	21	Helical; Potential
	Transmembrane	363 – 383	21	Helical; Potential
	Transmembrane	385 – 405	21	Helical; Potential
	Transmembrane	423 – 443	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	D0ZE09 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: A637B8C1D1B402F4	FASTA	443	48,853
	10 20 30 40 50 60 MSSTDSVVAG QAKVTTWRKT DTRWVLGLFG TAIGAGVLFF PISAGIGGLL PIIFMLILAF 70 80 90 100 110 120 PIAFFCHRAL ARLCLSGRSI SDNITDTVDQ HFGHVGGVVI TFLYFFAICP LLWIYGVTIT 130 140 150 160 170 180 NTFIAFWQHQ LLLPAINRGV VALAILLVMA FFIYFGKDLM VKVMGYLVFP FITCLVLISL 190 200 210 220 230 240 SLIPYWTGDI FTSFDMHSLS LFGSHGILVT VWLGIAIMVF SFNFSPIVSS FVVSKREEYE 250 260 270 280 290 300 ADFGREYTEQ KCAKIISRAS VLMVVVVMFF AFSCLFTLSP QDMAQAKQQN IPILSYLANH 310 320 330 340 350 360 FSSLGSGKST YATVLEYGAS IIALVAIFKS FFGHYLGTLE GLNGLIIKFG YHGEKSQAPM 370 380 390 400 410 420 KKLNMISMVI IMGSTWVIAY INPNILDLIG AMGAPIIAAL LCLLPMYAVW RVPALAKYKG 430 440 KASNYFVTII GLLTILNIVY QLM

References

[1]

"Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches." Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S., Zhao G., Liu Q., Zhang Y. PLoS ONE 4:E7646-E7646(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EIB202.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001135 Genomic DNA. Translation: ACY83740.1. Different initiation.
RefSeq	YP_003294951.1. NC_013508.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACY83740; ACY83740; ETAE_0895.
GeneID	8607246.
KEGG	etr:ETAE_0895.
PATRIC	32077050. VBIEdwTar116525_0832.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000270787.
KO	K03838.
OMA	WENQLQL.
Enzyme and pathway databases
BioCyc	ETAR498217:GJC4-929-MONOMER.
Family and domain databases
HAMAP	MF_01583. Thr_Ser_transp_TdcC.
InterPro	IPR023726. Thr/Ser_transpt_TdcC. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDCC_EDWTE

Accession

Primary (citable) accession number: D0ZE09

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program