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Protein
Submitted name:

Transmembrane glycoprotein

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Transmembrane glycoproteinImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CMRX-ray2.00A1-226[»]
2MK3NMR-A138-165[»]
A181-214[»]
3MA9X-ray2.05A1-217[»]
3MACX-ray2.50A1-217[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWW0.

Sequencei

Sequence statusi: Complete.

D0VWW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLSGIVQQ QNNLLRAIEA QQHLLQLTVW GIKQLQARIL AGGSGGHTTW
60 70 80 90 100
MEWDREINNY TSLIHSLIEE SQNQQEKNEQ ELLEGSSGGQ LLSGIVQQQN
110 120 130 140 150
NLLRAIEAQQ HLLQLTVWGI KQLQARILAG GSGGHTTWME WDREINNYTS
160 170 180 190 200
LIHSLIEESQ NQQEKNEQEL LEGSSGGQLL SGIVQQQNNL LRAIEAQQHL
210 220
LQLTVWGIKQ LQARILAGGH HHHHHG
Length:226
Mass (Da):25,454
Last modified:December 15, 2009 - v1
Checksum:iBE14255B939C3B04
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CMRX-ray2.00A1-226[»]
2MK3NMR-A138-165[»]
A181-214[»]
3MA9X-ray2.05A1-217[»]
3MACX-ray2.50A1-217[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWW0.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody."
    Luftig M.A., Mattu M., Di Giovine P., Geleziunas R., Hrin R., Barbato G., Bianchi E., Miller M.D., Pessi A., Carfi A.
    Nat. Struct. Mol. Biol. 13:740-747(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  2. "Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41."
    Gustchina E., Li M., Louis J.M., Anderson D.E., Lloyd J., Frisch C., Bewley C.A., Gustchina A., Wlodawer A., Clore G.M.
    PLoS Pathog. 6:e1001182-e1001182(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-217.
  3. "Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion."
    Roche J., Louis J.M., Grishaev A., Ying J., Bax A.
    Proc. Natl. Acad. Sci. U.S.A. 111:3425-3430(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 138-165 AND 181-214.

Entry informationi

Entry nameiD0VWW0_9HIV1
AccessioniPrimary (citable) accession number: D0VWW0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: March 16, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.