Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene

SDHC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).1 Publication

Cofactori

hemeNote: The heme is bound between the two transmembrane subunits SDHC and SDHD.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127Iron (heme axial ligand); shared with SDHD1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Alternative name(s):
Succinate-ubiquinone oxidoreductase cytochrome B large subunit
Short name:
CYBL
Gene namesi
Name:SDHC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 62Mitochondrial matrixCuratedAdd BLAST33
Transmembranei63 – 92HelicalAdd BLAST30
Topological domaini93 – 112Mitochondrial intermembraneCuratedAdd BLAST20
Transmembranei113 – 137HelicalAdd BLAST25
Topological domaini138 – 144Mitochondrial matrixCurated7
Transmembranei145 – 166HelicalAdd BLAST22
Topological domaini167 – 169Mitochondrial intermembraneCurated3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2366564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000039175030 – 169Succinate dehydrogenase cytochrome b560 subunit, mitochondrialAdd BLAST140

Proteomic databases

PaxDbiD0VWV4
PeptideAtlasiD0VWV4
PRIDEiD0VWV4

Expressioni

Tissue specificityi

Detected in heart muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSSSCG00000030318
GenevisibleiD0VWV4 SS

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.1 Publication

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000027481

Chemistry databases

BindingDBiD0VWV4

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 46Combined sources13
Turni47 – 49Combined sources3
Turni56 – 58Combined sources3
Helixi63 – 91Combined sources29
Beta strandi92 – 94Combined sources3
Helixi96 – 104Combined sources9
Turni105 – 107Combined sources3
Helixi110 – 138Combined sources29
Turni139 – 142Combined sources4
Helixi145 – 166Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZOYX-ray2.40C30-169[»]
1ZP0X-ray3.50C30-169[»]
3ABVX-ray3.24C30-169[»]
3AE1X-ray3.14C30-169[»]
3AE2X-ray3.10C30-169[»]
3AE3X-ray3.35C30-169[»]
3AE4X-ray2.91C30-169[»]
3AE5X-ray3.41C30-169[»]
3AE6X-ray3.40C30-169[»]
3AE7X-ray3.62C30-169[»]
3AE8X-ray3.40C30-169[»]
3AE9X-ray3.31C30-169[»]
3AEAX-ray3.39C30-169[»]
3AEBX-ray3.00C30-169[»]
3AECX-ray3.61C30-169[»]
3AEDX-ray3.52C30-169[»]
3AEEX-ray3.22C30-169[»]
3AEFX-ray2.80C30-169[»]
3AEGX-ray3.27C30-169[»]
3SFDX-ray2.61C30-169[»]
3SFEX-ray2.81C30-169[»]
4YTPX-ray3.10C1-169[»]
4YXDX-ray3.00C1-169[»]
SMRiD0VWV4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWV4

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0449 Eukaryota
COG2009 LUCA
GeneTreeiENSGT00390000000566
InParanoidiD0VWV4
KOiK00236
OMAiIPGGIPC
OrthoDBiEOG091G0SR6
TreeFamiTF313317

Family and domain databases

Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR034804 SQR/QFR_C/D
IPR018495 Succ_DH_cyt_bsu_CS
IPR014314 Succ_DH_cytb556
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000178 SDH_cyt_b560, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
TIGRFAMsiTIGR02970 succ_dehyd_cytB, 1 hit
PROSITEiView protein in PROSITE
PS01000 SDH_CYT_1, 1 hit
PS01001 SDH_CYT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0VWV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALLLRHVG RHCLRAHLSP QLCIRNAVPL GTTAKEEMER FWNKNLGSNR
60 70 80 90 100
PLSPHITIYR WSLPMAMSIC HRGTGIALSA GVSLFGLSAL LLPGNFESHL
110 120 130 140 150
ELVKSLCLGP TLIYTAKFGI VFPLMYHTWN GIRHLIWDLG KGLTIPQLTQ
160
SGVVVLILTV LSSVGLAAM
Length:169
Mass (Da):18,518
Last modified:March 2, 2010 - v2
Checksum:i42EB611C1DCDF0A5
GO

Sequence databases

RefSeqiXP_003125707.2, XM_003125659.5
UniGeneiSsc.23817

Genome annotation databases

EnsembliENSSSCT00000045783; ENSSSCP00000053659; ENSSSCG00000030318
GeneIDi100524676
KEGGissc:100524676

Similar proteinsi

Entry informationi

Entry nameiC560_PIG
AccessioniPrimary (citable) accession number: D0VWV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health