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Protein

DNA polymerase

Gene
N/A
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))Imported
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi428 ↔ 442Combined sources
Disulfide bondi506 ↔ 509Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WN7X-ray2.75A1-774[»]
4K8ZX-ray2.29A1-774[»]
SMRiD0VWU9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWU9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 129DNA_pol_B_exo1InterPro annotationAdd BLAST108
Domaini130 – 278DNA_pol_B_exo1InterPro annotationAdd BLAST149
Domaini352 – 746DNA_pol_BInterPro annotationAdd BLAST395

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00328. Archaea.
arCOG03145. Archaea.
COG0417. LUCA.
OrthoDBiPOG093Z00EA.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 1 hit.
InterProiView protein in InterPro
IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom_sf.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PfamiView protein in Pfam
PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
PRINTSiPR00106. DNAPOLB.
SMARTiView protein in SMART
SM00486. POLBc. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS00116. DNA_POLYMERASE_B. 1 hit.

Sequencei

Sequence statusi: Complete.

D0VWU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILDTDYITE DGKPVIRIFK KENGEFKIEY DRTFEPYFYA LLKDDSAIEE
60 70 80 90 100
VKKITAERHG TVVTVKRVEK VQKKFLGRPV EVWKLYFTHP QDVPAIRDKI
110 120 130 140 150
REHPAVIDIY EYDIPFAKRY LIDKGLVPME GDEELKMLAF DIETLYEEGE
160 170 180 190 200
EFAEGPILMI SYADEEGARV ITWKNVDLPY VDVVSTEREM IKRFLRVVKE
210 220 230 240 250
KDPDVLITYN GDNFDFAYLK KRCEKLGINF ALGRDGSEPK IQRMGDRFAV
260 270 280 290 300
EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGQPKEKV YAEEITTAWE
310 320 330 340 350
TGENLERVAR YSMEDAKVTY ELGKEFLPME AQLSRLIGQS LWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYERNELAPN KPDEKELARR RQSYEGGYVK EPERGLWENI
410 420 430 440 450
VYLDFRSLYP SIIITHNVSP DTLNREGCKE YDVAPQVGHR FCKDFPGFIP
460 470 480 490 500
SLLGDLLEER QKIKKKMKAT IDPIERKLLD YRQRAIKILA NSYYGYYGYA
510 520 530 540 550
RARWYCKECA ESVTAWGREY ITMTIKEIEE KYGFKVIYSD TDGFFATIPG
560 570 580 590 600
ADAETVKKKA MEFLKYINAK LPGALELEYE GFYERGFFVT KKKYAVIDEE
610 620 630 640 650
GKITTRGLEI VRRDWSEIAK ETQARVLEAL LKDGDVEKAV RIVKEVTEKL
660 670 680 690 700
SKYEVPPEKL VIHEQITRDL KDYKATGPHV AVAKRLAARG VKIRPGTVIS
710 720 730 740 750
YIVLKGSGRI GDRAIPFDEF DPTKHKYDAE YYIENQVLPA VERILRAFGY
760 770
RKEDLRYQKT RQVGLSAWLK PKGT
Length:774
Mass (Da):90,015
Last modified:December 15, 2009 - v1
Checksum:i8DF347CC091484CF
GO

Similar proteinsi

Entry informationi

Entry nameiD0VWU9_THEKO
AccessioniPrimary (citable) accession number: D0VWU9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sourcesImported