Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal protein L18

Gene

RPL18

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CFA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CFA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CFA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-CFA-72689. Formation of a pool of free 40S subunits.
R-CFA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CFA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CFA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein L18
Gene namesi
Name:RPL18
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055891 – 188Ribosomal protein L18Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei130PhosphoserineBy similarity1
Modified residuei158PhosphothreonineBy similarity1
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiD0VWQ3.
PRIDEiD0VWQ3.

Expressioni

Gene expression databases

BgeeiENSCAFG00000003967.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005899.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V5Zelectron microscopy8.70o1-188[»]
SMRiD0VWQ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWQ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1714. Eukaryota.
COG1727. LUCA.
GeneTreeiENSGT00390000012976.
HOVERGENiHBG000875.
InParanoidiD0VWQ3.
KOiK02883.
OMAiKHHVKKG.
OrthoDBiEOG091G07WU.
TreeFamiTF300202.

Family and domain databases

InterProiView protein in InterPro
IPR036227. L18e/L15P_sf.
IPR000039. Ribosomal_L18e.
IPR021131. Ribosomal_L18e/L15P.
IPR021132. Ribosomal_L18e_CS.
PANTHERiPTHR10934. PTHR10934. 1 hit.
PfamiView protein in Pfam
PF17135. Ribosomal_L18. 1 hit.
SUPFAMiSSF52080. SSF52080. 1 hit.
PROSITEiView protein in PROSITE
PS01106. RIBOSOMAL_L18E. 1 hit.

Sequencei

Sequence statusi: Complete.

D0VWQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR
60 70 80 90 100
LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV
110 120 130 140 150
CALRVSSRAR SRILKAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR
160 170 180
HFGKAPGTPH SHTKPYVRSK GRKFERARGR RASRGYKN
Length:188
Mass (Da):21,592
Last modified:February 22, 2012 - v2
Checksum:iB3FB31DFEA45A32C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30K → M in ABD77168 (PubMed:16751257).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ403035 mRNA. Translation: ABD77168.1.
RefSeqiNP_001238887.1. NM_001251958.1.
UniGeneiCfa.39179.

Genome annotation databases

EnsembliENSCAFT00000006369; ENSCAFP00000005899; ENSCAFG00000003967.
GeneIDi476422.
KEGGicfa:476422.

Similar proteinsi

Entry informationi

Entry nameiRL18_CANLF
AccessioniPrimary (citable) accession number: D0VWQ3
Secondary accession number(s): Q0QEV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 22, 2012
Last modified: November 22, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families