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Protein

Uricase

Gene

uox

Organism
Arthrobacter globiformis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.By similarity

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathwayi: urate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-allantoin from urate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (uox)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801Charge relay systemBy similarity
Binding sitei180 – 1801Substrate
Active sitei223 – 2231Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BRENDAi1.7.3.3. 444.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
Uricase (EC:1.7.3.3)
Alternative name(s):
Urate oxidase
Short name:
AgUOX
Gene namesi
Name:uox
OrganismiArthrobacter globiformis
Taxonomic identifieri1665 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302UricasePRO_0000406889Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1
302
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 3119Combined sources
Beta strandi33 – 364Combined sources
Beta strandi38 – 5013Combined sources
Helixi53 – 575Combined sources
Helixi67 – 7812Combined sources
Helixi85 – 9915Combined sources
Beta strandi103 – 11816Combined sources
Beta strandi122 – 14019Combined sources
Beta strandi143 – 16119Combined sources
Beta strandi176 – 1783Combined sources
Beta strandi182 – 19312Combined sources
Helixi199 – 21618Combined sources
Helixi222 – 23615Combined sources
Beta strandi240 – 24910Combined sources
Beta strandi252 – 2543Combined sources
Helixi258 – 2603Combined sources
Beta strandi268 – 2714Combined sources
Beta strandi274 – 28512Combined sources
Helixi293 – 2953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YZBX-ray1.90A/B/C/D/E/F/G/H1-302[»]
2YZCX-ray1.88A/B/C/D/E/F/G/H1-302[»]
2YZDX-ray2.24A/B/C/D/E/F/G/H1-302[»]
2YZEX-ray1.99A/B/C/D/E/F/G/H1-302[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWQ1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Substrate binding
Regioni222 – 2232Substrate binding

Sequence similaritiesi

Belongs to the uricase family.Curated

Family and domain databases

InterProiIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiPS00366. URICASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0VWQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATAETSTG TKVVLGQNQY GKAEVRLVKV TRNTARHEIQ DLNVTSQLRG
60 70 80 90 100
DFEAAHTAGD NAHVVATDTQ KNTVYAFARD GFATTEEFLL RLGKHFTEGF
110 120 130 140 150
DWVTGGRWAA QQFFWDRIND HDHAFSRNKS EVRTAVLEIS GSEQAIVAGI
160 170 180 190 200
EGLTVLKSTG SEFHGFPRDK YTTLQETTDR ILATDVSARW RYNTVEVDFD
210 220 230 240 250
AVYASVRGLL LKAFAETHSL ALQQTMYEMG RAVIETHPEI DEIKMSLPNK
260 270 280 290 300
HHFLVDLQPF GQDNPNEVFY AADRPYGLIE ATIQREGSRA DHPIWSNIAG

FC
Length:302
Mass (Da):33,859
Last modified:December 15, 2009 - v1
Checksum:i767CD3F715608B9C
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YZBX-ray1.90A/B/C/D/E/F/G/H1-302[»]
2YZCX-ray1.88A/B/C/D/E/F/G/H1-302[»]
2YZDX-ray2.24A/B/C/D/E/F/G/H1-302[»]
2YZEX-ray1.99A/B/C/D/E/F/G/H1-302[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00394; UER00650.
BRENDAi1.7.3.3. 444.

Miscellaneous databases

EvolutionaryTraceiD0VWQ1.

Family and domain databases

InterProiIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURIC_ARTGO
AccessioniPrimary (citable) accession number: D0VWQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: December 15, 2009
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.