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Protein

Uricase

Gene

uox

Organism
Arthrobacter globiformis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.By similarity

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathwayi: urate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-allantoin from urate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (uox)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei180Charge relay systemBy similarity1
Binding sitei180Substrate1
Active sitei223Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BRENDAi1.7.3.3. 444.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
Uricase (EC:1.7.3.3)
Alternative name(s):
Urate oxidase
Short name:
AgUOX
Gene namesi
Name:uox
OrganismiArthrobacter globiformis
Taxonomic identifieri1665 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004068891 – 302UricaseAdd BLAST302

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 31Combined sources19
Beta strandi33 – 36Combined sources4
Beta strandi38 – 50Combined sources13
Helixi53 – 57Combined sources5
Helixi67 – 78Combined sources12
Helixi85 – 99Combined sources15
Beta strandi103 – 118Combined sources16
Beta strandi122 – 140Combined sources19
Beta strandi143 – 161Combined sources19
Beta strandi176 – 178Combined sources3
Beta strandi182 – 193Combined sources12
Helixi199 – 216Combined sources18
Helixi222 – 236Combined sources15
Beta strandi240 – 249Combined sources10
Beta strandi252 – 254Combined sources3
Helixi258 – 260Combined sources3
Beta strandi268 – 271Combined sources4
Beta strandi274 – 285Combined sources12
Helixi293 – 295Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZBX-ray1.90A/B/C/D/E/F/G/H1-302[»]
2YZCX-ray1.88A/B/C/D/E/F/G/H1-302[»]
2YZDX-ray2.24A/B/C/D/E/F/G/H1-302[»]
2YZEX-ray1.99A/B/C/D/E/F/G/H1-302[»]
SMRiD0VWQ1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWQ1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 68Substrate binding2
Regioni222 – 223Substrate binding2

Sequence similaritiesi

Belongs to the uricase family.Curated

Family and domain databases

InterProiIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiPS00366. URICASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0VWQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATAETSTG TKVVLGQNQY GKAEVRLVKV TRNTARHEIQ DLNVTSQLRG
60 70 80 90 100
DFEAAHTAGD NAHVVATDTQ KNTVYAFARD GFATTEEFLL RLGKHFTEGF
110 120 130 140 150
DWVTGGRWAA QQFFWDRIND HDHAFSRNKS EVRTAVLEIS GSEQAIVAGI
160 170 180 190 200
EGLTVLKSTG SEFHGFPRDK YTTLQETTDR ILATDVSARW RYNTVEVDFD
210 220 230 240 250
AVYASVRGLL LKAFAETHSL ALQQTMYEMG RAVIETHPEI DEIKMSLPNK
260 270 280 290 300
HHFLVDLQPF GQDNPNEVFY AADRPYGLIE ATIQREGSRA DHPIWSNIAG

FC
Length:302
Mass (Da):33,859
Last modified:December 15, 2009 - v1
Checksum:i767CD3F715608B9C
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZBX-ray1.90A/B/C/D/E/F/G/H1-302[»]
2YZCX-ray1.88A/B/C/D/E/F/G/H1-302[»]
2YZDX-ray2.24A/B/C/D/E/F/G/H1-302[»]
2YZEX-ray1.99A/B/C/D/E/F/G/H1-302[»]
SMRiD0VWQ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00394; UER00650.
BRENDAi1.7.3.3. 444.

Miscellaneous databases

EvolutionaryTraceiD0VWQ1.

Family and domain databases

InterProiIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURIC_ARTGO
AccessioniPrimary (citable) accession number: D0VWQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: December 15, 2009
Last modified: November 2, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.