Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate decarboxylase

Gene

GAD1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:GAD1Imported
Ordered Locus Names:YMR250WImported
OrganismiSaccharomyces cerevisiae (Baker's yeast)Imported
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000004862. GAD1.

PTM / Processingi

Proteomic databases

PaxDbiD0VFN3.
PRIDEiD0VFN3.

Expressioni

Gene expression databases

ExpressionAtlasiD0VFN3. differential.

Structurei

3D structure databases

ProteinModelPortaliD0VFN3.
SMRiD0VFN3. Positions 59-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
PhylomeDBiD0VFN3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

D0VFN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHRHGSKQK NFENIAGKVV HDLAGLQLLS NDVQKSAVQS GHQGSNNMRD
60 70 80 90 100
TSSQGMANKY SVPKKGLPAD LSYQLIHNEL TLDGNPHLNL ASFVNTFTTD
110 120 130 140 150
QARKLIDENL TKNLADNDEY PQLIELTQRC ISMLAQLWHA NPDEEPIGCA
160 170 180 190 200
TTGSSEAIML GGLAMKKRWE HRMKNAGKDA SKPNIIMSSA CQVALEKFTR
210 220 230 240 250
YFEVECRLVP VSHRSHHMLD PESLWDYVDE NTIGCFVILG TTYTGHLENV
260 270 280 290 300
EKVADVLSQI EAKHPDWSNT DIPIHADGAS GGFIIPFGFE KEHMKAYGME
310 320 330 340 350
RWGFNHPRVV SMNTSGHKFG LTTPGLGWVL WRDESLLADE LRFKLKYLGG
360 370 380 390 400
VEETFGLNFS RPGFQVVHQY FNFVSLGHSG YRTQFQNSLF VARAFSFELL
410 420 430 440 450
NSSKLPGCFE IVSSIHESIE NDSAPKSVKD YWEHPQAYKP GVPLVAFKLS
460 470 480 490 500
KKFHEEYPEV PQAILSSLLR GRGWIIPNYP LPKATDGSDE KEVLRVVFRS
510 520 530 540 550
EMKLDLAQLL IVDIESILTK LIHSYEKVCH HIELASEQTP ERKSSFIYEM
560 570 580
LLALASPQDD IPTPDEIEKK NKLKETTTRN YRGTC
Length:585
Mass (Da):65,990
Last modified:December 15, 2009 - v1
Checksum:iDDD22868CEB7B955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU074586 Genomic DNA. Translation: ACY54291.1.
KM408173 Genomic DNA. Translation: AIY53684.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU074586 Genomic DNA. Translation: ACY54291.1.
KM408173 Genomic DNA. Translation: AIY53684.1.

3D structure databases

ProteinModelPortaliD0VFN3.
SMRiD0VFN3. Positions 59-521.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiD0VFN3.
PRIDEiD0VFN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

SGDiS000004862. GAD1.

Phylogenomic databases

eggNOGiCOG0076.
PhylomeDBiD0VFN3.

Gene expression databases

ExpressionAtlasiD0VFN3. differential.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Screening of a high yield gamma-aminobutyricacid yeast from the fruit surface and optimization of its cultural conditions."
    Jiang D.H., Li J., Hou J.H., Xu X.B.
    Zhejiang Nong Ye Da Xue Xue Bao 20:396-401(2008)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MJ2Imported.
  2. Li J., Jiang D.H., Zhou Q.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MJ2Imported.
  3. "Molecular Cloning of the Glutamic Acid Decarboxylase GAD1 Gene from Saccharomyces cerevisiae."
    Bao W.
    Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 28Imported.

Entry informationi

Entry nameiD0VFN3_YEASX
AccessioniPrimary (citable) accession number: D0VFN3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.