ID D0UZS0_HHV8 Unreviewed; 455 AA. AC D0UZS0; DT 15-DEC-2009, integrated into UniProtKB/TrEMBL. DT 15-DEC-2009, sequence version 1. DT 24-JAN-2024, entry version 57. DE SubName: Full=Core gene UL54 family protein {ECO:0000313|EMBL:ADQ57938.1}; DE SubName: Full=ORF57 {ECO:0000313|EMBL:ACY00456.1}; GN Name=ORF57 {ECO:0000313|EMBL:ADQ57938.1}; GN ORFNames=HHV8GK18_gp61 {ECO:0000313|EMBL:QGX86291.1}; OS Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus; OC Rhadinovirus humangamma8. OX NCBI_TaxID=37296 {ECO:0000313|EMBL:ACY00456.1, ECO:0000313|Proteomes:UP000141755}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ACY00456.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00456.1}; RA Brulois K., Lee A., Chang H.; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ADQ57938.1, ECO:0000313|Proteomes:UP000146550} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KSHV-BAC36 {ECO:0000313|EMBL:ADQ57938.1}; RX PubMed=21307197; DOI=10.1128/JVI.02068-10; RA Yakushko Y., Hackmann C., Gunther T., Ruckert J., Henke M., Koste L., RA Alkharsah K., Bohne J., Grundhoff A., Schulz T.F., Henke-Gendo C.; RT "Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome RT contains a duplication of a long unique-region fragment within the terminal RT repeat region."; RL J. Virol. 85:4612-4617(2011). RN [3] {ECO:0000313|EMBL:ACY00456.1, ECO:0000313|Proteomes:UP000141755} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00456.1}; RX PubMed=22740391; DOI=10.1128/JVI.01019-12; RA Brulois K.F., Chang H., Lee A.S., Ensser A., Wong L.Y., Toth Z., Lee S.H., RA Lee H.R., Myoung J., Ganem D., Oh T.K., Kim J.F., Gao S.J., Jung J.U.; RT "Construction and Manipulation of a New Kaposi's Sarcoma-Associated RT Herpesvirus Bacterial Artificial Chromosome Clone."; RL J. Virol. 86:9708-9720(2012). RN [4] {ECO:0000313|EMBL:AFQ99187.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KSHV-BAC36-deltaK15 {ECO:0000313|EMBL:AFQ99187.1}; RX PubMed=23028325; DOI=10.1371/journal.ppat.1002927; RA Bala K., Bosco R., Gramolelli S., Haas D.A., Kati S., Pietrek M., RA Havemeier A., Yakushko Y., Singh V.V., Dittrich-Breiholz O., Kracht M., RA Schulz T.F.; RT "Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced RT angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 RT expression."; RL PLoS Pathog. 8:E1002927-E1002927(2012). RN [5] {ECO:0000313|EMBL:ALH44915.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ZM116 {ECO:0000313|EMBL:ALH44915.1}, and ZM118 RC {ECO:0000313|EMBL:ALH45091.1}; RX PubMed=26423952; DOI=10.1128/JVI.01712-15; RA Olp L.N., Jeanniard A., Marimo C., West J.T., Wood C.; RT "Whole-Genome Sequencing of Kaposi's Sarcoma-Associated Herpesvirus from RT Zambian Kaposi's Sarcoma Biopsy Specimens Reveals Unique Viral Diversity."; RL J. Virol. 89:12299-12308(2015). RN [6] {ECO:0000313|EMBL:AKE33094.1, ECO:0000313|Proteomes:UP000155579} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25736227; DOI=10.1016/j.jviromet.2015.02.022; RA Kati S., Hage E., Mynarek M., Ganzenmueller T., Indenbirken D., RA Grundhoff A., Schulz T.F.; RT "Generation of high-titre virus stocks using BrK.219, a B-cell line RT infected stably with recombinant Kaposi's sarcoma-associated herpesvirus."; RL J. Virol. Methods 217:79-86(2015). RN [7] {ECO:0000313|EMBL:QGX86291.1} RP NUCLEOTIDE SEQUENCE. RA Beauclair G., Naimo E., Dubich T., Rueckert J., Koch S., Dhingra A., RA Wirth D., Schulz T.F.; RT "Targeting the Kaposi Sarcoma Herpesvirus ORF 21 tyrosine kinase and viral RT lytic reactivation by tyrosine kinase inhibitors approved for clinical RT use."; RL J. Virol. 0:0-0(2019). RN [8] {ECO:0000313|EMBL:QKE51172.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BC3 {ECO:0000313|EMBL:QKE51172.1}, P044_PEL RC {ECO:0000313|EMBL:QKE51346.1}, P100_PEL {ECO:0000313|EMBL:QKE51694.1}, RC and P133_MCD {ECO:0000313|EMBL:QKE51781.1}; RA Jary A., Leducq V., Desire N., Palich R., Joly V., Canestri A., RA Gothland A., Lambert-Niclot S., Surgers L., Amiel C., Descamps D., RA Spano J.-P., Katlama C., Calvez V., Marcelin A.-G.; RT "Spread of a new Kaposi's sarcoma-associated herpesvirus variant driving RT severe pathologies in men who have sex with men."; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:QGX86291.1} RP NUCLEOTIDE SEQUENCE. RA Goetting J., Naimo E., Schulz T.F.; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:QLF96550.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FNL002 {ECO:0000313|EMBL:QLF96550.1}, FNL003 RC {ECO:0000313|EMBL:QLF96634.1}, FNL004 {ECO:0000313|EMBL:QLF96718.1}, RC FNL005 {ECO:0000313|EMBL:QLF96802.1}, FNL006 RC {ECO:0000313|EMBL:QLF96886.1}, FNL007 {ECO:0000313|EMBL:QLF96971.1}, RC FNL009 {ECO:0000313|EMBL:QLF97056.1}, and FNL011 RC {ECO:0000313|EMBL:QLF97141.1}; RA Cornejo Castro E.M., Marshall V., Lack J., Lurain K., Immonen T., Labo N., RA Fisher N.C., Ramaswami R., Wyvill K.M., Aleman K., Polizzotto M.N., Cam M., RA Keele B.F., Yarchoan R., Uldrick T.S., Whitby D.; RT "Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by RT whole-genome sequence analysis of effusion samples."; RL Virus Evol. 0:0-0(2020). RN [11] {ECO:0000313|EMBL:QLI55098.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BCBL1 {ECO:0000313|EMBL:QQL05612.1}, U004-C RC {ECO:0000313|EMBL:QLI55721.1}, U004-D {ECO:0000313|EMBL:QLI55899.1}, RC U004-o1 {ECO:0000313|EMBL:QLI55810.1}, U008-B RC {ECO:0000313|EMBL:QLI55098.1}, U008-D {ECO:0000313|EMBL:QLI55187.1}, RC U008-o1 {ECO:0000313|EMBL:QLI55276.1}, U030-C RC {ECO:0000313|EMBL:QLI56344.1}, U034-B {ECO:0000313|EMBL:QLI55365.1}, RC U034-C {ECO:0000313|EMBL:QLI55454.1}, U034-o1 RC {ECO:0000313|EMBL:QLI55543.1}, and U034-o2 RC {ECO:0000313|EMBL:QLI55632.1}; RA Santiago J.C.A.; RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:QLI55098.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BCBL1 {ECO:0000313|EMBL:QQL05612.1}, U004-C RC {ECO:0000313|EMBL:QLI55721.1}, U004-D {ECO:0000313|EMBL:QLI55899.1}, RC U004-o1 {ECO:0000313|EMBL:QLI55810.1}, U008-B RC {ECO:0000313|EMBL:QLI55098.1}, U008-D {ECO:0000313|EMBL:QLI55187.1}, RC U008-o1 {ECO:0000313|EMBL:QLI55276.1}, U030-C RC {ECO:0000313|EMBL:QLI56344.1}, U034-B {ECO:0000313|EMBL:QLI55365.1}, RC U034-C {ECO:0000313|EMBL:QLI55454.1}, U034-o1 RC {ECO:0000313|EMBL:QLI55543.1}, and U034-o2 RC {ECO:0000313|EMBL:QLI55632.1}; RA Goldman J.D., Zhao H., Pankow A.P., Okuku F., Schmitt M.W., Chen L.H., RA Hill C.A., Casper C., Phipps W.T., Mullins J.I.; RT "Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in RT Ugandan adults with Kaposi sarcoma."; RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ994935; ACY00456.1; -; Genomic_DNA. DR EMBL; HQ404500; ADQ57938.1; -; Genomic_DNA. DR EMBL; JX228174; AFQ99187.1; -; Genomic_DNA. DR EMBL; KF588566; AKE33094.1; -; Genomic_DNA. DR EMBL; KT271461; ALH44915.1; -; Genomic_DNA. DR EMBL; KT271463; ALH45091.1; -; Genomic_DNA. DR EMBL; MN752405; QGX86291.1; -; Genomic_DNA. DR EMBL; MK876731; QKE51172.1; -; Genomic_DNA. DR EMBL; MK876733; QKE51346.1; -; Genomic_DNA. DR EMBL; MK876737; QKE51694.1; -; Genomic_DNA. DR EMBL; MK876738; QKE51781.1; -; Genomic_DNA. DR EMBL; MN419219; QLF96550.1; -; Genomic_DNA. DR EMBL; MN419220; QLF96634.1; -; Genomic_DNA. DR EMBL; MN419221; QLF96718.1; -; Genomic_DNA. DR EMBL; MN419222; QLF96802.1; -; Genomic_DNA. DR EMBL; MN419223; QLF96886.1; -; Genomic_DNA. DR EMBL; MN419224; QLF96971.1; -; Genomic_DNA. DR EMBL; MN419225; QLF97056.1; -; Genomic_DNA. DR EMBL; MN419226; QLF97141.1; -; Genomic_DNA. DR EMBL; MT510656; QLI55098.1; -; Genomic_DNA. DR EMBL; MT510657; QLI55187.1; -; Genomic_DNA. DR EMBL; MT510658; QLI55276.1; -; Genomic_DNA. DR EMBL; MT510659; QLI55365.1; -; Genomic_DNA. DR EMBL; MT510660; QLI55454.1; -; Genomic_DNA. DR EMBL; MT510661; QLI55543.1; -; Genomic_DNA. DR EMBL; MT510662; QLI55632.1; -; Genomic_DNA. DR EMBL; MT510663; QLI55721.1; -; Genomic_DNA. DR EMBL; MT510664; QLI55810.1; -; Genomic_DNA. DR EMBL; MT510665; QLI55899.1; -; Genomic_DNA. DR EMBL; MT510670; QLI56344.1; -; Genomic_DNA. DR EMBL; MT936340; QQL05612.1; -; Genomic_DNA. DR RefSeq; YP_001129410.1; NC_009333.1. DR SMR; D0UZS0; -. DR IntAct; D0UZS0; 6. DR DNASU; 4961525; -. DR GeneID; 4961525; -. DR KEGG; vg:4961525; -. DR OrthoDB; 7128at10239; -. DR Proteomes; UP000141755; Genome. DR Proteomes; UP000146550; Genome. DR Proteomes; UP000155579; Genome. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR InterPro; IPR008648; ICP27-like. DR Pfam; PF05459; Herpes_UL69; 1. PE 4: Predicted; FT REGION 17..163 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 23..40 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 75..95 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 118..133 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 455 AA; 51012 MW; D3262C05AA472515 CRC64; MVQAMIDMDI MKGILEDSVS SSEFDESRDD ETDAPTLEDE QLSEPAEPPA DERIRGTQSA QGIPPPLGRI PKKSQGRSQL RSEIQFCSPL SRPRSPSPVN RYGKKIKFGT AGQNTRPPPE KRPRRRPRDR LQYGRTTRGG QCRAAPKRAT RRPQVNCQRQ DDDVRQGVSD AVKKLRLPAS MIIDGESPRF DDSIIPRHHG ACFNVFIPAP PSHVPEVFTD RDITALIRAG GKDDELINKK ISAKKIDHLH RQMLSFVTSR HNQAYWVSCR RETAAAGGLQ TLGAFVEEQM TWAQTVVRHG GWFDEKDIDI ILDTAIFVCN AFVTRFRLLH LSCVFDKQSE LALIKQVAYL VAMGNRLVEA CNLLGEVKLN FRGGLLLAFV LTIPGMQSRR SISARGQELF RTLLEYYRPG DVMGLLNVIV MEHHSLCRNS ECAAATRAAM GSAKFNKGLF FYPLS //