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D0R4X6

- D0R4X6_LACJF

UniProt

D0R4X6 - D0R4X6_LACJF

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Protein
Thymidine kinase
Gene
tdk, FI9785_1279
Organism
Lactobacillus johnsonii (strain FI9785)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptor By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi154 – 1541Zinc By similarityUniRule annotation
Metal bindingi188 – 1881Zinc By similarityUniRule annotation
Metal bindingi191 – 1911Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi93 – 964ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLJOH633699:GJ95-1208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:FI9785_1279Imported
OrganismiLactobacillus johnsonii (strain FI9785)Imported
Taxonomic identifieri633699 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002627: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi633699.FI9785_1279.

Structurei

3D structure databases

ProteinModelPortaliD0R4X6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0R4X6-1 [UniParc]FASTAAdd to Basket

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MAQLFFRYGA MSSGKSIEIL KVAHNYEAQG RKIALMTSNV DDRSGVGTVA    50
SRIGLHRKAV PISEDLNLFN YVSELNKSDV ETGNGRVACV LIDEAQFLKR 100
HHVLECAKIV DELKIPVMAF GLKNDFQNHL FEGSENLLIF ADKVEEMKTI 150
CHYCGHKATM NLRINSGKPV YEGEQVQIGG DESYYPVCRF HYFHPNKQR 199
Length:199
Mass (Da):22,498
Last modified:December 15, 2009 - v1
Checksum:i8B94962F5C2B3B91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN298497 Genomic DNA. Translation: CAX67139.1.
RefSeqiYP_003293406.1. NC_013504.1.

Genome annotation databases

EnsemblBacteriaiCAX67139; CAX67139; FI9785_1279.
GeneIDi8571171.
KEGGiljf:FI9785_1279.
PATRICi32247149. VBILacJoh137736_1205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN298497 Genomic DNA. Translation: CAX67139.1 .
RefSeqi YP_003293406.1. NC_013504.1.

3D structure databases

ProteinModelPortali D0R4X6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 633699.FI9785_1279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX67139 ; CAX67139 ; FI9785_1279 .
GeneIDi 8571171.
KEGGi ljf:FI9785_1279.
PATRICi 32247149. VBILacJoh137736_1205.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci LJOH633699:GJ95-1208-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactobacillus johnsonii FI9785, a competitive exclusion agent against pathogens in poultry."
    Wegmann U., Overweg K., Horn N., Goesmann A., Narbad A., Gasson M.J., Shearman C.
    J. Bacteriol. 191:7142-7143(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FI9785Imported.

Entry informationi

Entry nameiD0R4X6_LACJF
AccessioniPrimary (citable) accession number: D0R4X6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi