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Protein

Conotoxin im23.3

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin im23.3
Alternative name(s):
Conotoxin im21.3
Conotoxin im23a
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041704523 – 28By similarity6
ChainiPRO_000041712831 – 70Conotoxin im23.3Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Disulfide bondi45 ↔ 53By similarity
Disulfide bondi54 ↔ 69By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiD0PX86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XXIII (C-C-C-CC-C).Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0PX86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMRMTLTLF VLVVMTAASA SGDALTEAKR IPYCGQTGAE CYSWCKEQHL
60 70
IRCCDFVKYV GMNPPADKCR
Length:70
Mass (Da):7,825
Last modified:December 15, 2009 - v1
Checksum:i78163B4ABF61B09E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ375240 mRNA. Translation: ACQ66000.1.

Similar proteinsi

Entry informationi

Entry nameiCAN3_CONIM
AccessioniPrimary (citable) accession number: D0PX86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

There is a discrepancy in nomenclature: was submitted as im23a but is named im21.3 in PubMed:22399292.1 Publication

Documents

  1. SIMILARITY comments
    Index of protein domains and families