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Protein

Conotoxin im23b

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections.1 Publication

Miscellaneous

Does not affect (up to 50 µM) the Nav1.7/SCN9A channel, Drosophila Shaker channel and rat KCa1.1/KCNMA1 channel expressed in HEK293 cell, as well as on whole cell current of neurons from neonatal rat hippocampus and prefrontal cortex. In addition, no detectable effect is observed on either action potential amplitude and duration or Na+ and Ca2+ current amplitude and kinetics when im23a is tested on action potentials and depolarization-activated Na+ and Ca2+ currents in rat DRG neurons (PubMed:22399292).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin im23b
Alternative name(s):
Im23.2
U1-CTX-Ci1b
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041703323 – 286
ChainiPRO_500082565031 – 73Conotoxin im23bAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Disulfide bondi45 ↔ 55By similarity
Disulfide bondi56 ↔ 71By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD0PX85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XXIII (C-C-C-CC-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0PX85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMRMTLTLF VLVVMTAASA SGDALTEAKR IPYCGQTGAE CYSWCIKQDL
60 70
SKDWCCDFVK TIARLPPAHI CSQ
Length:73
Mass (Da):8,091
Last modified:December 15, 2009 - v1
Checksum:iC61962220B1065B2
GO

Mass spectrometryi

Molecular mass is 4874.0 Da from positions 31 - 72. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ375239 mRNA. Translation: ACQ65999.1.

Similar proteinsi

Entry informationi

Entry nameiCANB_CONIM
AccessioniPrimary (citable) accession number: D0PX85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families