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Protein

Conotoxin im23a

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections.1 Publication

Miscellaneous

Does not affect (up to 50 µM) the Nav1.7/SCN9A channel, Drosophila Shaker channel and rat KCa1.1/KCNMA1 channel expressed in HEK293 cell, as well as on whole cell current of neurons from neonatal rat hippocampus and prefrontal cortex. In addition, no detectable effect is observed on either action potential amplitude and duration or Na+ and Ca2+ current amplitude and kinetics when im23a is tested on action potentials and depolarization-activated Na+ and Ca2+ currents in rat DRG neurons (PubMed:22399292).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin im23a
Alternative name(s):
Im23.1
U1-CTX-Ci1a
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041703223 – 286
ChainiPRO_500082564931 – 72Conotoxin im23aAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 411 Publication
Disulfide bondi45 ↔ 551 Publication
Disulfide bondi56 ↔ 711 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 47Combined sources10
Helixi52 – 61Combined sources10
Turni68 – 70Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMZNMR-A31-72[»]
SMRiD0PX84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XXIII (C-C-C-CC-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0PX84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMRMTLTLF VLVVMTAASA SGDALTEAKR IPYCGQTGAE CYSWCIKQDL
60 70
SKDWCCDFVK DIRMNPPADK CP
Length:72
Mass (Da):8,040
Last modified:December 15, 2009 - v1
Checksum:iF906BE740065B2C4
GO

Mass spectrometryi

Molecular mass is 4823.0 Da from positions 31 - 72. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ375238 mRNA. Translation: ACQ65998.1.

Similar proteinsi

Entry informationi

Entry nameiCANA_CONIM
AccessioniPrimary (citable) accession number: D0PX84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families