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Protein

DNA ligase

Gene

PITG_03514

Organism
Phytophthora infestans (strain T30-4) (Potato late blight fungus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PITG_03514Imported
OrganismiPhytophthora infestans (strain T30-4) (Potato late blight fungus)Imported
Taxonomic identifieri403677 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora
ProteomesiUP000006643: Partially assembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000179646.
InParanoidiD0MXT4.
KOiK10777.
OMAiLQEENQY.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0MXT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVEDAALD QSAALGLSFT ALCSVLKAVE ATRKNDSKLD MLFSSSLRAQ
60 70 80 90 100
VGGGDLYPLI RLVLPQLDRE RTYMLKEKKI AKIYIDVLGL APISKDAQKL
110 120 130 140 150
EHFNDPKIVD SKSVGDFAAV LFDVVLYQSA RTKSKTHHTL EDVNTLLDRL
160 170 180 190 200
VQADNNAARK KVFMKLATEY SADEQKWIIR VILKDLKIGL RHERVLKFIH
210 220 230 240 250
PDAMEMYNHT NDLHKVCKEL RNSAVRYVPQ LEPFQVFTPM LAKRVNFGEC
260 270 280 290 300
ISAINADAFV MEPKLDGERI TCHVQGKEVQ FISRNGINYT ENYAPSIKPH
310 320 330 340 350
VLSQLEPGID CILDGEMMVW DNTEYRLREF GLLKNTANAV RKGEATNRWL
360 370 380 390 400
CYVVWDVVYV GGGPKAEQLI REVFKDPGEI SAVMGLPLHA RRKLLLRILK
410 420 430 440 450
PLDHRIIIIE QKLVNDKSAK ERHEKVMAEV DQQVSNGGEG VIMKDLNAHY
460 470 480 490 500
MCGESSRKAK KWLKLKPDYA GMTTDLDVII VGGFYGTGRR RSGNVSVFLL
510 520 530 540 550
GVLAHSLDEK KAAEATKPGA ACPVVYTFAK VGTGYNLEEL EQMRQELEPY
560 570 580 590 600
WQPWDDDNVP SHLNGWKPQK SDLRPDVWID PRHSKILEVY GFELSFTTLY
610 620 630 640 650
QTGLTIRFPR CKAIRNDKEW YQCIDLQDLN AARGSLSTKR ASEVALGQKS
660 670 680 690 700
ATKRIKKRQT VSARRPNGVL QDYSRADLEG IEQERNVFEG MEFCVLPGKY
710 720 730 740 750
QKPPQDLASS FPDGIFEKNA MQLSKQTVEK LLHSFGGAIV QNPIAGSTHY
760 770 780 790 800
VVAAGDSGFK VVNLKKQGLF NVVHIRWVFN CIVASRLVSL KAGDFISATD
810 820 830 840 850
LQRQLLAKEY DRYGDHFTEH VTPDDLRRIL QELSSASERK HTSLPWQFKL
860 870 880 890 900
KELEMEEAEA MDSAFTFLAH CVVYFHNSSS SEDKDIDVLA MGQMKLIEQQ
910 920 930 940 950
LKLYGGVVAR EIDSSATHVV ADPAQVEQLA PAIRNLRHQG LPEPRVVTKE
960 970
WVQECVEQRT QVPDNNFVVH V
Length:971
Mass (Da):109,708
Last modified:December 15, 2009 - v1
Checksum:iB36315463F7AD926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028121 Genomic DNA. Translation: EEY65982.1.
RefSeqiXP_002906581.1. XM_002906535.1.

Genome annotation databases

EnsemblProtistsiPITG_03514T0; PITG_03514T0; PITG_03514.
GeneIDi9467476.
KEGGipif:PITG_03514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028121 Genomic DNA. Translation: EEY65982.1.
RefSeqiXP_002906581.1. XM_002906535.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPITG_03514T0; PITG_03514T0; PITG_03514.
GeneIDi9467476.
KEGGipif:PITG_03514.

Phylogenomic databases

HOGENOMiHOG000179646.
InParanoidiD0MXT4.
KOiK10777.
OMAiLQEENQY.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans."
    The Broad Institute Genome Sequencing Platform
    Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A., Baxter L., Beynon J.
    , Boevink P.C., Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K., Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D., Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L., Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J., Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M., Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S., Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D., Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S., Nusbaum C.
    Nature 461:393-398(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T30-4Imported.

Entry informationi

Entry nameiD0MXT4_PHYIT
AccessioniPrimary (citable) accession number: D0MXT4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.