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D0MVS1 (KEX1_PHYIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:PITG_02213
OrganismPhytophthora infestans (strain T30-4) (Potato late blight fungus) [Reference proteome]
Taxonomic identifier403677 [NCBI]
Taxonomic lineageEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 597579Pheromone-processing carboxypeptidase KEX1
PRO_0000411936

Regions

Topological domain19 – 508490Lumenal Potential
Transmembrane509 – 52921Helical; Potential
Topological domain530 – 59768Cytoplasmic Potential

Sites

Active site1861 By similarity
Active site3771 By similarity
Active site4361 By similarity

Amino acid modifications

Glycosylation3951N-linked (GlcNAc...) Potential
Glycosylation4251N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D0MVS1 [UniParc].

Last modified December 15, 2009. Version 1.
Checksum: C8C0A32D77A6B9FA

FASTA59766,514
        10         20         30         40         50         60 
MVTRHVLAAA LAGSMTSAQR LHPTSQRASD DLIQNLPGLD PAAKVTQHAG RIALHDNDKN 

        70         80         90        100        110        120 
KMFYWHFQAA QDPEKAPLVI WLNGGPGCTS MQGLFLGNSP FTLKDDSTIG KNEHSWHEFA 

       130        140        150        160        170        180 
NLLFVDQPIG TGMSYTKGND YRLDEETIAQ DFYEFLTKFL QRHNKYLSDG DDGVSNSRAV 

       190        200        210        220        230        240 
YMFGESHAGR WIPEFSDHIM KQNNDPKNQI KINLDGVGIG NGWVHPRIQY EYSDYAHGLG 

       250        260        270        280        290        300 
LLTFGQVRSL KASYAECLAA LDAGTYYSRS CLDNMDSITG SVKPGNGGNS LNFYDVRQYL 

       310        320        330        340        350        360 
RNVGSYPSGQ SNIAKYMNKM EVRKAVHGNE DKNFRFDLCS NGVFRALSKF DGVSTLDKVE 

       370        380        390        400        410        420 
SLLQQGLRMI FYNGQWDMMC NHYGTEKLLL NLNWNGSDAY QQADKYTWRV QGRKEPAGFA 

       430        440        450        460        470        480 
QQGGNLTYLV VTGAGHMVPM DVPDVAADIL RRFVNRLEFN DKVQTVVTTR LNATDMEVSF 

       490        500        510        520        530        540 
CYSPSVSADP DTSLSTRDQT GANSSQVHIG IAWLWVALVI AVVSSVLAVC VTIVCIRNKR 

       550        560        570        580        590 
NGKQEHEMIT QVSDDEEVNQ IEDESEEGFS DEDVGVHVLV SNVSQRATSP RSRVTEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS028120 Genomic DNA. Translation: EEY63734.1.
RefSeqXP_002907170.1. XM_002907124.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.A68.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPITG_02213T0; PITG_02213T0; PITG_02213.
GeneID9469606.
KEGGpif:PITG_02213.

Phylogenomic databases

HOGENOMHOG000200446.
OMAPINIAGI.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PHYIT
AccessionPrimary (citable) accession number: D0MVS1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries