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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Phytophthora infestans (strain T30-4) (Potato late blight fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861PROSITE-ProRule annotation
Active sitei377 – 3771PROSITE-ProRule annotation
Active sitei436 – 4361PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiphyit-kex1. Carboxypeptidase_S10.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PITG_02213
OrganismiPhytophthora infestans (strain T30-4) (Potato late blight fungus)
Taxonomic identifieri403677 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora
ProteomesiUP000006643 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PITG_02213.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 508490LumenalSequence AnalysisAdd
BLAST
Transmembranei509 – 52921HelicalSequence AnalysisAdd
BLAST
Topological domaini530 – 59768CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 597579Pheromone-processing carboxypeptidase KEX1PRO_0000411936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000200446.
InParanoidiD0MVS1.
KOiK01288.
OMAiESHAGRW.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0MVS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTRHVLAAA LAGSMTSAQR LHPTSQRASD DLIQNLPGLD PAAKVTQHAG
60 70 80 90 100
RIALHDNDKN KMFYWHFQAA QDPEKAPLVI WLNGGPGCTS MQGLFLGNSP
110 120 130 140 150
FTLKDDSTIG KNEHSWHEFA NLLFVDQPIG TGMSYTKGND YRLDEETIAQ
160 170 180 190 200
DFYEFLTKFL QRHNKYLSDG DDGVSNSRAV YMFGESHAGR WIPEFSDHIM
210 220 230 240 250
KQNNDPKNQI KINLDGVGIG NGWVHPRIQY EYSDYAHGLG LLTFGQVRSL
260 270 280 290 300
KASYAECLAA LDAGTYYSRS CLDNMDSITG SVKPGNGGNS LNFYDVRQYL
310 320 330 340 350
RNVGSYPSGQ SNIAKYMNKM EVRKAVHGNE DKNFRFDLCS NGVFRALSKF
360 370 380 390 400
DGVSTLDKVE SLLQQGLRMI FYNGQWDMMC NHYGTEKLLL NLNWNGSDAY
410 420 430 440 450
QQADKYTWRV QGRKEPAGFA QQGGNLTYLV VTGAGHMVPM DVPDVAADIL
460 470 480 490 500
RRFVNRLEFN DKVQTVVTTR LNATDMEVSF CYSPSVSADP DTSLSTRDQT
510 520 530 540 550
GANSSQVHIG IAWLWVALVI AVVSSVLAVC VTIVCIRNKR NGKQEHEMIT
560 570 580 590
QVSDDEEVNQ IEDESEEGFS DEDVGVHVLV SNVSQRATSP RSRVTEV
Length:597
Mass (Da):66,514
Last modified:December 15, 2009 - v1
Checksum:iC8C0A32D77A6B9FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028120 Genomic DNA. Translation: EEY63734.1.
RefSeqiXP_002907170.1. XM_002907124.1.

Genome annotation databases

EnsemblProtistsiPITG_02213T0; PITG_02213T0; PITG_02213.
GeneIDi9469606.
KEGGipif:PITG_02213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028120 Genomic DNA. Translation: EEY63734.1.
RefSeqiXP_002907170.1. XM_002907124.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiphyit-kex1. Carboxypeptidase_S10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPITG_02213T0; PITG_02213T0; PITG_02213.
GeneIDi9469606.
KEGGipif:PITG_02213.

Organism-specific databases

EuPathDBiFungiDB:PITG_02213.

Phylogenomic databases

HOGENOMiHOG000200446.
InParanoidiD0MVS1.
KOiK01288.
OMAiESHAGRW.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans."
    The Broad Institute Genome Sequencing Platform
    Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A., Baxter L., Beynon J.
    , Boevink P.C., Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K., Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D., Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L., Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J., Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M., Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S., Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D., Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S., Nusbaum C.
    Nature 461:393-398(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T30-4.

Entry informationi

Entry nameiKEX1_PHYIT
AccessioniPrimary (citable) accession number: D0MVS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 15, 2009
Last modified: July 22, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.