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D0MVS1

- KEX1_PHYIT

UniProt

D0MVS1 - KEX1_PHYIT

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Phytophthora infestans (strain T30-4) (Potato late blight fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei186 – 1861PROSITE-ProRule annotation
    Active sitei377 – 3771PROSITE-ProRule annotation
    Active sitei436 – 4361PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.A68.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:PITG_02213
    OrganismiPhytophthora infestans (strain T30-4) (Potato late blight fungus)
    Taxonomic identifieri403677 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora
    ProteomesiUP000006643: Partially assembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 597579Pheromone-processing carboxypeptidase KEX1PRO_0000411936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 508490LumenalSequence AnalysisAdd
    BLAST
    Topological domaini530 – 59768CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei509 – 52921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000200446.
    OMAiPINIAGI.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D0MVS1-1 [UniParc]FASTAAdd to Basket

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    MVTRHVLAAA LAGSMTSAQR LHPTSQRASD DLIQNLPGLD PAAKVTQHAG    50
    RIALHDNDKN KMFYWHFQAA QDPEKAPLVI WLNGGPGCTS MQGLFLGNSP 100
    FTLKDDSTIG KNEHSWHEFA NLLFVDQPIG TGMSYTKGND YRLDEETIAQ 150
    DFYEFLTKFL QRHNKYLSDG DDGVSNSRAV YMFGESHAGR WIPEFSDHIM 200
    KQNNDPKNQI KINLDGVGIG NGWVHPRIQY EYSDYAHGLG LLTFGQVRSL 250
    KASYAECLAA LDAGTYYSRS CLDNMDSITG SVKPGNGGNS LNFYDVRQYL 300
    RNVGSYPSGQ SNIAKYMNKM EVRKAVHGNE DKNFRFDLCS NGVFRALSKF 350
    DGVSTLDKVE SLLQQGLRMI FYNGQWDMMC NHYGTEKLLL NLNWNGSDAY 400
    QQADKYTWRV QGRKEPAGFA QQGGNLTYLV VTGAGHMVPM DVPDVAADIL 450
    RRFVNRLEFN DKVQTVVTTR LNATDMEVSF CYSPSVSADP DTSLSTRDQT 500
    GANSSQVHIG IAWLWVALVI AVVSSVLAVC VTIVCIRNKR NGKQEHEMIT 550
    QVSDDEEVNQ IEDESEEGFS DEDVGVHVLV SNVSQRATSP RSRVTEV 597
    Length:597
    Mass (Da):66,514
    Last modified:December 15, 2009 - v1
    Checksum:iC8C0A32D77A6B9FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS028120 Genomic DNA. Translation: EEY63734.1.
    RefSeqiXP_002907170.1. XM_002907124.1.

    Genome annotation databases

    EnsemblProtistsiPITG_02213T0; PITG_02213T0; PITG_02213.
    GeneIDi9469606.
    KEGGipif:PITG_02213.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS028120 Genomic DNA. Translation: EEY63734.1 .
    RefSeqi XP_002907170.1. XM_002907124.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.A68.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PITG_02213T0 ; PITG_02213T0 ; PITG_02213 .
    GeneIDi 9469606.
    KEGGi pif:PITG_02213.

    Phylogenomic databases

    HOGENOMi HOG000200446.
    OMAi PINIAGI.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans."
      The Broad Institute Genome Sequencing Platform
      Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A., Baxter L., Beynon J.
      , Boevink P.C., Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K., Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D., Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L., Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J., Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M., Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S., Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D., Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S., Nusbaum C.
      Nature 461:393-398(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T30-4.

    Entry informationi

    Entry nameiKEX1_PHYIT
    AccessioniPrimary (citable) accession number: D0MVS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3