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D0MVS1

- KEX1_PHYIT

UniProt

D0MVS1 - KEX1_PHYIT

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, PITG_02213
Organism
Phytophthora infestans (strain T30-4) (Potato late blight fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861 By similarity
Active sitei377 – 3771 By similarity
Active sitei436 – 4361 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A68.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PITG_02213
OrganismiPhytophthora infestans (strain T30-4) (Potato late blight fungus)
Taxonomic identifieri403677 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora
ProteomesiUP000006643: Partially assembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 508490Lumenal Reviewed prediction
Add
BLAST
Transmembranei509 – 52921Helical; Reviewed prediction
Add
BLAST
Topological domaini530 – 59768Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 597579Pheromone-processing carboxypeptidase KEX1
PRO_0000411936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi425 – 4251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi503 – 5031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000200446.
OMAiPINIAGI.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0MVS1-1 [UniParc]FASTAAdd to Basket

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MVTRHVLAAA LAGSMTSAQR LHPTSQRASD DLIQNLPGLD PAAKVTQHAG    50
RIALHDNDKN KMFYWHFQAA QDPEKAPLVI WLNGGPGCTS MQGLFLGNSP 100
FTLKDDSTIG KNEHSWHEFA NLLFVDQPIG TGMSYTKGND YRLDEETIAQ 150
DFYEFLTKFL QRHNKYLSDG DDGVSNSRAV YMFGESHAGR WIPEFSDHIM 200
KQNNDPKNQI KINLDGVGIG NGWVHPRIQY EYSDYAHGLG LLTFGQVRSL 250
KASYAECLAA LDAGTYYSRS CLDNMDSITG SVKPGNGGNS LNFYDVRQYL 300
RNVGSYPSGQ SNIAKYMNKM EVRKAVHGNE DKNFRFDLCS NGVFRALSKF 350
DGVSTLDKVE SLLQQGLRMI FYNGQWDMMC NHYGTEKLLL NLNWNGSDAY 400
QQADKYTWRV QGRKEPAGFA QQGGNLTYLV VTGAGHMVPM DVPDVAADIL 450
RRFVNRLEFN DKVQTVVTTR LNATDMEVSF CYSPSVSADP DTSLSTRDQT 500
GANSSQVHIG IAWLWVALVI AVVSSVLAVC VTIVCIRNKR NGKQEHEMIT 550
QVSDDEEVNQ IEDESEEGFS DEDVGVHVLV SNVSQRATSP RSRVTEV 597
Length:597
Mass (Da):66,514
Last modified:December 15, 2009 - v1
Checksum:iC8C0A32D77A6B9FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS028120 Genomic DNA. Translation: EEY63734.1.
RefSeqiXP_002907170.1. XM_002907124.1.

Genome annotation databases

EnsemblProtistsiPITG_02213T0; PITG_02213T0; PITG_02213.
GeneIDi9469606.
KEGGipif:PITG_02213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS028120 Genomic DNA. Translation: EEY63734.1 .
RefSeqi XP_002907170.1. XM_002907124.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.A68.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PITG_02213T0 ; PITG_02213T0 ; PITG_02213 .
GeneIDi 9469606.
KEGGi pif:PITG_02213.

Phylogenomic databases

HOGENOMi HOG000200446.
OMAi PINIAGI.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans."
    The Broad Institute Genome Sequencing Platform
    Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M., Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O., Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A., Baxter L., Beynon J.
    , Boevink P.C., Bollmann S.R., Bos J.I., Bulone V., Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S., Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K., Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D., Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L., Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J., Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M., Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S., Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D., Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J., Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S., Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P., Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S., Nusbaum C.
    Nature 461:393-398(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T30-4.

Entry informationi

Entry nameiKEX1_PHYIT
AccessioniPrimary (citable) accession number: D0MVS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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