ID   D0MIK6_RHOM4            Unreviewed;       663 AA.
AC   D0MIK6;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   OrderedLocusNames=Rmar_1427 {ECO:0000313|EMBL:ACY48314.1};
OS   Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus
OS   obamensis).
OC   Bacteria; Rhodothermota; Rhodothermia; Rhodothermales; Rhodothermaceae;
OC   Rhodothermus.
OX   NCBI_TaxID=518766 {ECO:0000313|EMBL:ACY48314.1, ECO:0000313|Proteomes:UP000002221};
RN   [1] {ECO:0000313|EMBL:ACY48314.1, ECO:0000313|Proteomes:UP000002221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43812 / DSM 4252 / R-10
RC   {ECO:0000313|Proteomes:UP000002221};
RX   PubMed=21304669; DOI=10.4056/sigs.46736;
RA   Nolan M., Tindall B.J., Pomrenke H., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Lucas S., Chen F., Tice H., Cheng J.F., Saunders E.,
RA   Han C., Bruce D., Goodwin L., Chain P., Pitluck S., Ovchinikova G.,
RA   Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Detter J.C.;
RT   "Complete genome sequence of Rhodothermus marinus type strain (R-10).";
RL   Stand. Genomic Sci. 1:283-291(2009).
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DR   EMBL; CP001807; ACY48314.1; -; Genomic_DNA.
DR   RefSeq; WP_012843925.1; NC_013501.1.
DR   AlphaFoldDB; D0MIK6; -.
DR   STRING; 518766.Rmar_1427; -.
DR   KEGG; rmr:Rmar_1427; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_3_6_10; -.
DR   OrthoDB; 9778383at2; -.
DR   Proteomes; UP000002221; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   CDD; cd05968; AACS_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACY48314.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002221};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        167..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          47..102
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          111..498
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          551..629
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   663 AA;  74251 MW;  E138E2CC912A6C74 CRC64;
     MQIGSAFSLT TGTFPFNQPV VWEPRPEWIA ASNLQRFMNR HGIGSLDELQ ARSVDDPEWF
     WPAVLEDLDI RFYRPYTRIL DLSEGPAFPR WCVGGQLNIV HNLLDKWQET DAAERIALRW
     EGEEGTLRTL TYAGLHAEVC RCARALQSLG FQKGDVAALF MPMTPELVIA FLAVIKLGGI
     VLPLFSGYGA EAVRTRIRDA EARFLFTADG FYRRGRPVYL KPVADEALAN CPSVQHVIVY
     RRMEADNVPV PMLPGRDHWW HELVWPQPAE AETVRTDAED VLMVIYTSGT TGRPKGAVHT
     HCGFPVKAAQ DMYQCMDLKP GETMYWVTDM GWMMGPWLVF GTLLIGATMV LYDGAPDYPD
     VDRLWGLVEQ HRVTHLGISP TLIRALRPHG PEPIRRHDLS SLRAVGSTGS PWDPESWLWC
     FEHVLGREKP ILNYSGGTEI SGGILCGNFF RPLKPCAFSG PVPGMAADVV DEQGRPVREA
     VGELVIRKPW IGMTRGFWRD RERYLDTYWR RIEGLWVHGD FAAIDRDGLW YILGRSDDTI
     KVAGKRVGPA EVEAILNAHE AVAESAAIGV PHEVKGEEVV AFVVLKPGVS PSEELRRELI
     ERVVAALGKP LKPREIRFTT ALPKTRNAKI MRRVIRAAYL GQDPGDVSSL EDPAAVEAIR
     QAV
//