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D0MFZ0

- D0MFZ0_RHOM4

UniProt

D0MFZ0 - D0MFZ0_RHOM4

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Protein
Thymidine kinase
Gene
tdk, Rmar_2606
Organism
Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptor By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi154 – 1541Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 298ATP By similarityUniRule annotation
Nucleotide bindingi94 – 974ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRMAR518766:GJJ8-2655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Rmar_2606Imported
OrganismiRhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)Imported
Taxonomic identifieri518766 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeRhodothermus
ProteomesiUP000002221: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi518766.Rmar_2606.

Structurei

3D structure databases

ProteinModelPortaliD0MFZ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0MFZ0-1 [UniParc]FASTAAdd to Basket

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MPMEPLILRH GGSVGWIEVI CGSMFSGKTE ELIRRLRRAQ IARQRVEVFK    50
PRMDRRYSET DVVSHDENAL RSTPVDSAEQ ILLLAGSADV VGIDEAQFFD 100
MTLVDVCQQL ANDGKRVIVA GLDQDYMGRP FEPMPQLMAV AEYVTKLHAI 150
CAVCGAPANH SQRLTDEEGR VVLGAADRYE PRCRRCFQPP RPTSTSSLKA 200
PAPAATAPRP ELP 213
Length:213
Mass (Da):23,572
Last modified:December 15, 2009 - v1
Checksum:iB4984C39F9AFD482
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001807 Genomic DNA. Translation: ACY49479.1.
RefSeqiYP_003291867.1. NC_013501.1.

Genome annotation databases

EnsemblBacteriaiACY49479; ACY49479; Rmar_2606.
GeneIDi8569274.
KEGGirmr:Rmar_2606.
PATRICi32319359. VBIRhoMar93821_2633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001807 Genomic DNA. Translation: ACY49479.1 .
RefSeqi YP_003291867.1. NC_013501.1.

3D structure databases

ProteinModelPortali D0MFZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 518766.Rmar_2606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY49479 ; ACY49479 ; Rmar_2606 .
GeneIDi 8569274.
KEGGi rmr:Rmar_2606.
PATRICi 32319359. VBIRhoMar93821_2633.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci RMAR518766:GJJ8-2655-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43812 / DSM 4252 / R-10.

Entry informationi

Entry nameiD0MFZ0_RHOM4
AccessioniPrimary (citable) accession number: D0MFZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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