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D0MFZ0

- D0MFZ0_RHOM4

UniProt

D0MFZ0 - D0MFZ0_RHOM4

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Protein

Thymidine kinase

Gene

tdk

Organism
Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptorUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi154 – 1541ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 298ATPUniRule annotation
Nucleotide bindingi94 – 974ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRMAR518766:GJJ8-2655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Rmar_2606Imported
OrganismiRhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)Imported
Taxonomic identifieri518766 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeRhodothermus
ProteomesiUP000002221: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi518766.Rmar_2606.

Structurei

3D structure databases

ProteinModelPortaliD0MFZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0MFZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMEPLILRH GGSVGWIEVI CGSMFSGKTE ELIRRLRRAQ IARQRVEVFK
60 70 80 90 100
PRMDRRYSET DVVSHDENAL RSTPVDSAEQ ILLLAGSADV VGIDEAQFFD
110 120 130 140 150
MTLVDVCQQL ANDGKRVIVA GLDQDYMGRP FEPMPQLMAV AEYVTKLHAI
160 170 180 190 200
CAVCGAPANH SQRLTDEEGR VVLGAADRYE PRCRRCFQPP RPTSTSSLKA
210
PAPAATAPRP ELP
Length:213
Mass (Da):23,572
Last modified:December 15, 2009 - v1
Checksum:iB4984C39F9AFD482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001807 Genomic DNA. Translation: ACY49479.1.
RefSeqiYP_003291867.1. NC_013501.1.

Genome annotation databases

EnsemblBacteriaiACY49479; ACY49479; Rmar_2606.
GeneIDi8569274.
KEGGirmr:Rmar_2606.
PATRICi32319359. VBIRhoMar93821_2633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001807 Genomic DNA. Translation: ACY49479.1 .
RefSeqi YP_003291867.1. NC_013501.1.

3D structure databases

ProteinModelPortali D0MFZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 518766.Rmar_2606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACY49479 ; ACY49479 ; Rmar_2606 .
GeneIDi 8569274.
KEGGi rmr:Rmar_2606.
PATRICi 32319359. VBIRhoMar93821_2633.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci RMAR518766:GJJ8-2655-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43812 / DSM 4252 / R-10Imported.

Entry informationi

Entry nameiD0MFZ0_RHOM4
AccessioniPrimary (citable) accession number: D0MFZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3