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Protein

D-alanine--D-alanine ligase

Gene

Rmar_0135

Organism
Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathway: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRMAR518766:GJJ8-140-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Rmar_0135Imported
OrganismiRhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) (Rhodothermus obamensis)Imported
Taxonomic identifieri518766 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeRhodothermus
ProteomesiUP000002221 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi518766.Rmar_0135.

Structurei

3D structure databases

ProteinModelPortaliD0MCT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OrthoDBiEOG66MQKK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0MCT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPNGLMRIG IVYDLFDDYP WEVGEPPDAD AENEPPETVD VLAAAIRKLG
60 70 80 90 100
HKPVRIGTAY DLLVELPDLR IDCGISIAEG ARGRNREAYA PMLFEMAGIP
110 120 130 140 150
YIGSDPLTLS LSLDKAWTKD LVAAAGVPTP PYRTYAGPED VDPHDLPGPF
160 170 180 190 200
PLFVKPRYEG SSKGITAASK VHSLEALREQ VARLTATYRQ EVIVEPFIEG
210 220 230 240 250
SEFTVAVIGN NPPEPLPVLQ RAVEATTGIG LHALEHRGMK PAAALEAAPY
260 270 280 290 300
VPLTDELERC LQQLAVRVYE KLQCRDFARL DFRVDREGKP WFLEINPLPT
310 320 330
FAPDGTFAIL AELMQRPYVE FLAEILQRGL RRLGLA
Length:336
Mass (Da):37,128
Last modified:December 15, 2009 - v1
Checksum:i77C050818A9843E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001807 Genomic DNA. Translation: ACY47043.1.
RefSeqiWP_012842655.1. NC_013501.1.
YP_003289431.1. NC_013501.1.

Genome annotation databases

EnsemblBacteriaiACY47043; ACY47043; Rmar_0135.
KEGGirmr:Rmar_0135.
PATRICi32314281. VBIRhoMar93821_0134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001807 Genomic DNA. Translation: ACY47043.1.
RefSeqiWP_012842655.1. NC_013501.1.
YP_003289431.1. NC_013501.1.

3D structure databases

ProteinModelPortaliD0MCT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi518766.Rmar_0135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY47043; ACY47043; Rmar_0135.
KEGGirmr:Rmar_0135.
PATRICi32314281. VBIRhoMar93821_0134.

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OrthoDBiEOG66MQKK.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciRMAR518766:GJJ8-140-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43812 / DSM 4252 / R-10Imported.

Entry informationi

Entry nameiD0MCT3_RHOM4
AccessioniPrimary (citable) accession number: D0MCT3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.