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Protein

Thymidine kinase

Gene

tdk

Organism
Vibrio sp. (strain Ex25)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi182 – 1821ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciVSP150340:GJJG-2334-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:VEA_003836Imported
OrganismiVibrio sp. (strain Ex25)Imported
Taxonomic identifieri150340 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002571 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi150340.VEA_003836.

Structurei

3D structure databases

ProteinModelPortaliD0M4F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0M4F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMYFYYSA MNAGKSTTLL QSSFNYQERG MTPVIFTAAL DDRFGVGKVS
60 70 80 90 100
SRIGLQSDAH LFRQDTNLYQ EIAALNEVEK RHCILVDECQ FLSKEQVYQL
110 120 130 140 150
TEVVDKLHIP VLCYGLRTDF LGELFEGSKY LLSWADKLVE LKTICHCGRK
160 170 180 190
ANMVIRTDEH GVAIKEGDQV AIGGNDKYVS VCRQHYKEAL GK
Length:192
Mass (Da):21,775
Last modified:December 15, 2009 - v1
Checksum:i2E51D744123E3783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001805 Genomic DNA. Translation: ACY51996.1.
RefSeqiWP_005378154.1. NC_013456.1.
YP_003286461.1. NC_013456.1.

Genome annotation databases

EnsemblBacteriaiACY51996; ACY51996; VEA_003836.
KEGGivex:VEA_003836.
PATRICi32537725. VBIVibSp203755_2232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001805 Genomic DNA. Translation: ACY51996.1.
RefSeqiWP_005378154.1. NC_013456.1.
YP_003286461.1. NC_013456.1.

3D structure databases

ProteinModelPortaliD0M4F5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi150340.VEA_003836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY51996; ACY51996; VEA_003836.
KEGGivex:VEA_003836.
PATRICi32537725. VBIVibSp203755_2232.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.
OrthoDBiEOG69D3J2.

Enzyme and pathway databases

BioCyciVSP150340:GJJG-2334-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the deep-sea isolate Vibrio sp. strain Ex25."
    Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R., Huq A., Grim C.J., Hasan N.A., Vonstein V., Bartels D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ex25Imported.

Entry informationi

Entry nameiD0M4F5_VIBSE
AccessioniPrimary (citable) accession number: D0M4F5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 27, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.