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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:Hoch_3652Imported
OrganismiHaliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)Imported
Taxonomic identifieri502025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesNannocystineaeKofleriaceaeHaliangium
Proteomesi
  • UP000001880 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi502025.Hoch_3652.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 301CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST258

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 58Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4107QM9. Bacteria.
COG0825. LUCA.
HOGENOMiHOG000273832.
KOiK01962.
OMAiCSSILWR.
OrthoDBiPOG091H0647.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

D0LXB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTTEQQSRS DRMILEFERP VFELERKIEE LRGMSSEQVD MSAEIRKLEQ
60 70 80 90 100
KARKLQNEVF ADLSPQQKVQ LSRHPARPYM ADYLHLLVED FVELHGDRGF
110 120 130 140 150
RDDPAIVGGM ARFDGREVLV LGHQKGRNTK ENVHRNFGMP RPEGYRKATR
160 170 180 190 200
LMQMAARFRR PILCFIDTPG AYPGLGAEER GQAEAIAKSL EVMAGLPTPI
210 220 230 240 250
ISMVLGEGGS GGALALGVAD RILMFEYSIY SVISPEGCAS ILWRDPAKIP
260 270 280 290 300
EAAGQLKLTA ADLVGLGVCD EIVPEARGGA HRDPAKSASY LRSALKRQLS
310 320
ELEQLDTATL IEQRYRKYRA MGSFLESAG
Length:329
Mass (Da):36,602
Last modified:December 15, 2009 - v1
Checksum:i972600F858982C2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001804 Genomic DNA. Translation: ACY16154.1.

Genome annotation databases

EnsemblBacteriaiACY16154; ACY16154; Hoch_3652.
KEGGihoh:Hoch_3652.

Similar proteinsi

Entry informationi

Entry nameiD0LXB2_HALO1
AccessioniPrimary (citable) accession number: D0LXB2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported