Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UvrABC system protein C

Gene

uvrC

Organism
Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / JCM 3198 / NCTC 10667) (Rhodococcus bronchialis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nucleaseUniRule annotationSAAS annotation

Keywords - Biological processi

DNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGBRO526226:GHJF-2391-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotationSAAS annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Gbro_2359Imported
OrganismiGordonia bronchialis (strain ATCC 25592 / DSM 43247 / JCM 3198 / NCTC 10667) (Rhodococcus bronchialis)Imported
Taxonomic identifieri526226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeGordoniaceaeGordonia
ProteomesiUP000001219: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi526226.Gbro_2359.

Structurei

3D structure databases

ProteinModelPortaliD0LCT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580GIY-YIGUniRule annotationAdd
BLAST
Domaini208 – 24336UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation
Contains GIY-YIG domain.SAAS annotation
Contains UVR domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0LCT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADPTTYRPA PGTIPTEPGV YRFRDAHGRV IYVGKAKSLR SRLTSYFADI
60 70 80 90 100
ASLHPRTRQM VTTAASVEWT VVGTEVEALQ LEYNWIKEFD PRFNVRYRDD
110 120 130 140 150
KSYPMLAVTL NEEYPRLFVY RGPRRRGVRY FGPYSHAWAI RETVDLLTRV
160 170 180 190 200
FPARTCSAGV FKRHRQIDRP CLLGYIDKCA APCVGRVSAE QHREIVDDFC
210 220 230 240 250
DFLAGRTDQM IRRMEREMSA AATELDFERA ARLRDDIGAM RRAMEKQAVV
260 270 280 290 300
LGDGTDADVV AFAGDDLEVS VQIFHVRDGR VRGQRGWVVE RSDNGSVGDL
310 320 330 340 350
VGDFLTQFYG QQVDLDATVE IGAGRARGDA VPREVMVPEL PSDAAELEDW
360 370 380 390 400
LSELRGSRVR LRVPQRGDKK ALFDTVGRNA SEALAQHKLR RAGDLTTRSA
410 420 430 440 450
ALTELQESLG LDQAPLRIEC VDISHVQGTD VVASLVVFED GLPRKSDYRH
460 470 480 490 500
YSIRHAAGDG HSDDVASIAE VTRRRFLRHR ADQLPAPPPM ESGPAPTGTP
510 520 530 540 550
EADVAPPVPK KFAYPPNLFV VDGGAPQVHA AAAVLDELGI TDVSVIGLAK
560 570 580 590 600
RLEEVWTPGD DEPIILPRAG EALFLLQRVR DEAHRFAITF HRNKRSKRMT
610 620 630 640 650
ESVLDGVPGL GRTRKTALVT HFGSVARLRE ASLEDISGVP GIGMATARAV
660 670
QAALGEDGRD DAADVSGGDG D
Length:671
Mass (Da):74,093
Last modified:December 15, 2009 - v1
Checksum:iEB4B09594D872B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001802 Genomic DNA. Translation: ACY21601.1.
RefSeqiYP_003273494.1. NC_013441.1.

Genome annotation databases

EnsemblBacteriaiACY21601; ACY21601; Gbro_2359.
GeneIDi8551722.
KEGGigbr:Gbro_2359.
PATRICi32184331. VBIGorBro114338_2417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001802 Genomic DNA. Translation: ACY21601.1.
RefSeqiYP_003273494.1. NC_013441.1.

3D structure databases

ProteinModelPortaliD0LCT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi526226.Gbro_2359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY21601; ACY21601; Gbro_2359.
GeneIDi8551722.
KEGGigbr:Gbro_2359.
PATRICi32184331. VBIGorBro114338_2417.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Enzyme and pathway databases

BioCyciGBRO526226:GHJF-2391-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25592 / DSM 43247 / JCM 3198 / NCTC 10667Imported.

Entry informationi

Entry nameiD0LCT0_GORB4
AccessioniPrimary (citable) accession number: D0LCT0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.