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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / JCM 3198 / NCTC 10667) (Rhodococcus bronchialis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161D-inositol 3-phosphateUniRule annotation1
Binding sitei30UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei851D-inositol 3-phosphateUniRule annotation1
Binding sitei1181D-inositol 3-phosphateUniRule annotation1
Binding sitei1421D-inositol 3-phosphateUniRule annotation1
Binding sitei1621D-inositol 3-phosphateUniRule annotation1
Binding sitei236UDP-GlcNAcUniRule annotation1
Binding sitei241UDP-GlcNAcUniRule annotation1
Binding sitei302UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi311Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi312Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi314Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei324UDP-GlcNAcUniRule annotation1
Binding sitei332UDP-GlcNAcUniRule annotation1
Metal bindingi338MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciGBRO526226:G1GGH-984-MONOMER

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Gbro_0989
OrganismiGordonia bronchialis (strain ATCC 25592 / DSM 43247 / JCM 3198 / NCTC 10667) (Rhodococcus bronchialis)
Taxonomic identifieri526226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesGordoniaceaeGordonia
Proteomesi
  • UP000001219 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001261 – 458D-inositol 3-phosphate glycosyltransferaseAdd BLAST458

Proteomic databases

PRIDEiD0L476

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi526226.Gbro_0989

Structurei

3D structure databases

ProteinModelPortaliD0L476
SMRiD0L476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23UDP-GlcNAc bindingUniRule annotation2
Regioni27 – 321D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

D0L476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTGPLPRRV ALISVHTSPL AQPGTGDAGG MNVYVWQTAT RLARRGVEVE
60 70 80 90 100
IFTRATSSSD APRVAAAPRV TVRNVVAGPF EGLDKRDLPA QLCAFTAGVL
110 120 130 140 150
RAEAAQEPGY YDLIHSHYWL SGQVGWLARD RWGVPLVHTA HTLAAVKNAS
160 170 180 190 200
LAAGDTAEPQ LRVIGEQQVV DEADRLIANT ETEASELISM YGADPARIDV
210 220 230 240 250
VTPGADLDCY TPGPREMART SLGLDQNEAI VTFVGRIQPL KAPDLLIEAA
260 270 280 290 300
APLIRRSRTS RRPVRVLIVG GPSGSGLDRP TALIDLAHDL GIADAVTFLP
310 320 330 340 350
PQAPARLADV YRASNLVAVP SHSESFGLVA IEAQACGTPV LAADVGGLSV
360 370 380 390 400
AVAGGRTGVL VGSHAVGDWT NALEKALAQP DRLAEMGRNA RVHAEQFSWD
410 420 430 440 450
HTVDAMLSSY SRAMQSFAAR NPDAAQSVAA QNVTGSSSRT RRPWRRRRST

LLPMTGRS
Length:458
Mass (Da):48,663
Last modified:December 15, 2009 - v1
Checksum:iC636E4A1499D4566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001802 Genomic DNA Translation: ACY20300.1
RefSeqiWP_012832879.1, NC_013441.1

Genome annotation databases

EnsemblBacteriaiACY20300; ACY20300; Gbro_0989
KEGGigbr:Gbro_0989

Similar proteinsi

Entry informationi

Entry nameiMSHA_GORB4
AccessioniPrimary (citable) accession number: D0L476
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 15, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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