Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi11Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi86Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei211S-adenosyl-L-methionineUniRule annotation1
Binding sitei240S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei262S-adenosyl-L-methionineUniRule annotation1
Binding sitei310S-adenosyl-L-methionineUniRule annotation1
Active sitei337NucleophileUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHNEA555778:GIVV-1759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Ordered Locus Names:Hneap_1713
OrganismiHalothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
Taxonomic identifieri555778 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesHalothiobacillaceaeHalothiobacillus
Proteomesi
  • UP000009102 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004148201 – 37923S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST379

Interactioni

Protein-protein interaction databases

STRINGi555778.Hneap_1713.

Structurei

3D structure databases

ProteinModelPortaliD0L1G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiGLHCASP.
OrthoDBiPOG091H00VG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0L1G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCAYFERGT CRSCGWLADP YADQLQRKMA RCQSALTGLG GVWLPIVPSA
60 70 80 90 100
ETAFRNKAKM VVCGDASSPC LGILDADDDG IDLSNCPLYP TAITEAFEPL
110 120 130 140 150
KQMIRRLGIP PYDVKKRQGE LKYLLITVSE DDDSLMVRLV LRSDIWIERL
160 170 180 190 200
RADLSTLTAD LPHLAVLSVN IQPVHQAILE GEQEVILTDR ETLTVHLNGL
210 220 230 240 250
PFHLRPKSFF QTNTRVAEQL YATARSWVAE VAPVHMWDLF CGVGGFALHC
260 270 280 290 300
ADVIPGQVTG IEISAEAIAS AQQSALELGL KNVSFHALGA NEFIDQAVSL
310 320 330 340 350
PQMPALVVVN PPRRGLGVGL CAFLDESVVQ TVIYSSCNPE SLARDLVMMP
360 370
GFELVKAQVF DLFPHTAHSE VLAMLVRVR
Length:379
Mass (Da):41,605
Last modified:December 15, 2009 - v1
Checksum:iA318EB65EF7DE9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001801 Genomic DNA. Translation: ACX96536.1.
RefSeqiWP_012824569.1. NC_013422.1.

Genome annotation databases

EnsemblBacteriaiACX96536; ACX96536; Hneap_1713.
KEGGihna:Hneap_1713.
PATRICi32207358. VBIHalNea120669_1744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001801 Genomic DNA. Translation: ACX96536.1.
RefSeqiWP_012824569.1. NC_013422.1.

3D structure databases

ProteinModelPortaliD0L1G3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi555778.Hneap_1713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX96536; ACX96536; Hneap_1713.
KEGGihna:Hneap_1713.
PATRICi32207358. VBIHalNea120669_1744.

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiGLHCASP.
OrthoDBiPOG091H00VG.

Enzyme and pathway databases

BioCyciHNEA555778:GIVV-1759-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLMC_HALNC
AccessioniPrimary (citable) accession number: D0L1G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: December 15, 2009
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.