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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147UniRule annotation1
Active sitei595UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processCarbon dioxide fixationUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciHNEA555778:GIVV-1033-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Hneap_0998Imported
OrganismiHalothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)Imported
Taxonomic identifieri555778 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesHalothiobacillaceaeHalothiobacillus
Proteomesi
  • UP000009102 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi555778.Hneap_0998.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CCA. Bacteria.
COG2352. LUCA.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiPOG091H040O.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1. 1 hit.
InterProiView protein in InterPro
IPR021135. PEP_COase.
IPR022805. PEP_COase_bac/pln-type.
IPR018129. PEP_COase_Lys_AS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF00311. PEPcase. 1 hit.
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiView protein in PROSITE
PS00781. PEPCASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

D0KZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNSKDNDK ALRARVRLFG NLLGEVLKEQ TGDHVFDTVE TLRRGFIKLR
60 70 80 90 100
LKHNPKLHAK LMVLLRTLDP DTLNFVVRAY NLYFSLVNIA EEDFMHQHRR
110 120 130 140 150
KQVRLGLRLW RGSFYDTMRE FSKQGMSPDD LQTLLNRLIY MPVFTAHPTE
160 170 180 190 200
AKRRTVMDLQ RKIFLLCAEL DHPEAKGIER DRLHQQVKSV ILSLLKTNEV
210 220 230 240 250
RTTRPEVHDE IRLGLYYFST SIFDAVPLAY RYLERAVDVN FNEKFPDAPV
260 270 280 290 300
TVPSLFRFGS WIGGDRDGNP YVTHEVTTFA VCSATQTILQ EYLDRLAGMD
310 320 330 340 350
RVLTHSCRLC PEIDLEGLGL HQDAVELGLA SPENSGDSFF TEEPYRLKLR
360 370 380 390 400
IIGQRLKHNL DYVTALLDKK PINLSAHAYA HKDQFLSDLY RIRDTLISTG
410 420 430 440 450
DQLLADGEIK DLIRLAETFG WHLFKLDIRQ ESTRHTQTVA DILKQLQPKT
460 470 480 490 500
DYMALDEAGR MTLLTQLINK SRHKAIDMAA LSAESAETLE VFKVKRELID
510 520 530 540 550
TISRECFGTY VISMTHAASH VMEVMFLAVL AGLAGKRKSQ WFCDIQISPL
560 570 580 590 600
FETIEDLHQI ENVLSVLFEN PVYRELIRVS GDLQEAMLGY SDSCKDGGSL
610 620 630 640 650
ASVWSLYNAQ KRVLSITQKN GIECRLFHGR GGTVARGGGP THESILSLPA
660 670 680 690 700
GTVEGQIKFT EQGEVLSSKY SNTETAIYEI TMGATGLMKA SAHLVMENNP
710 720 730 740 750
APAEHEQVVA ELATYGEKAY RELTDETPFF FNYFFEATPV RELGLLNIGS
760 770 780 790 800
RPASRKVGDL SKASVRAIPW VFGWSQSRHT LPAWYGIGSA LRAWRQSHKD
810 820 830 840 850
QPELLHTLFN EWPFFHSMLR NTQLSLTKGE MTIAREYASL VADQAQALPV
860 870 880 890 900
YDKISTEYYR TLDELLRVAR VDSLVEIDEY IGTSMMRRNP YLDVLNHIQI
910 920 930
VLLRRYRDDS EPEAERQKWL LPLLRSINAI ASGMRNTG
Length:938
Mass (Da):106,985
Last modified:December 15, 2009 - v1
Checksum:i7103A2F2471FFF93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001801 Genomic DNA. Translation: ACX95834.1.
RefSeqiWP_012823870.1. NC_013422.1.

Genome annotation databases

EnsemblBacteriaiACX95834; ACX95834; Hneap_0998.
KEGGihna:Hneap_0998.
PATRICi32205858. VBIHalNea120669_1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001801 Genomic DNA. Translation: ACX95834.1.
RefSeqiWP_012823870.1. NC_013422.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi555778.Hneap_0998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX95834; ACX95834; Hneap_0998.
KEGGihna:Hneap_0998.
PATRICi32205858. VBIHalNea120669_1005.

Phylogenomic databases

eggNOGiENOG4105CCA. Bacteria.
COG2352. LUCA.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiPOG091H040O.

Enzyme and pathway databases

BioCyciHNEA555778:GIVV-1033-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1. 1 hit.
InterProiView protein in InterPro
IPR021135. PEP_COase.
IPR022805. PEP_COase_bac/pln-type.
IPR018129. PEP_COase_Lys_AS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
PfamiView protein in Pfam
PF00311. PEPcase. 1 hit.
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiView protein in PROSITE
PS00781. PEPCASE_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD0KZG1_HALNC
AccessioniPrimary (citable) accession number: D0KZG1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 15, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.