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D0KXK9

- D0KXK9_HALNC

UniProt

D0KXK9 - D0KXK9_HALNC

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Protein
Alanine racemase
Gene
Hneap_2388
Organism
Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei130 – 1301Substrate By similarityUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHNEA555778:GIVV-2440-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Hneap_2388Imported
OrganismiHalothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)Imported
Taxonomic identifieri555778 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesHalothiobacillaceaeHalothiobacillus
ProteomesiUP000009102: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi555778.Hneap_2388.

Structurei

3D structure databases

ProteinModelPortaliD0KXK9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiPVELWGQ.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D0KXK9-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPLVAHIR LDAFRHNYRL AKAAHGGRAL AVVKADAYGH GAVECARAIA    50
DEADGFAVAM IEEALSLRAA GITAPILLLE GFFDVSELLD IQIHNLWIVV 100
HHRWQVDALL AAHLTRPITV WLKMDSGMHR VGIAPDQYRA TYERLKNHPS 150
IAQIVLMSHF ARADEPESGH MLQQLETFHA ATMGIDAPVS LSNSAAVLGW 200
SGARADWARP GIMLYGADPF VGKAGASIAE QLRPVMRLEG GIISVRIIAR 250
GEPLGYGGAF VADRPTRVGV VSCGYADGYP RTAPTGTPVA VDGQLTRLIG 300
RVSMDMLTVD LTHLPQADIG SRVELWGDQV PVNAVASRVG TIAYELLCHV 350
KRARFEYSGQ TIHQETI 367
Length:367
Mass (Da):39,766
Last modified:December 15, 2009 - v1
Checksum:i416AF4FB3DEC2349
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001801 Genomic DNA. Translation: ACX97197.1.
RefSeqiWP_012825228.1. NC_013422.1.
YP_003264244.1. NC_013422.1.

Genome annotation databases

EnsemblBacteriaiACX97197; ACX97197; Hneap_2388.
GeneIDi8535552.
KEGGihna:Hneap_2388.
PATRICi32208798. VBIHalNea120669_2458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001801 Genomic DNA. Translation: ACX97197.1 .
RefSeqi WP_012825228.1. NC_013422.1.
YP_003264244.1. NC_013422.1.

3D structure databases

ProteinModelPortali D0KXK9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 555778.Hneap_2388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX97197 ; ACX97197 ; Hneap_2388 .
GeneIDi 8535552.
KEGGi hna:Hneap_2388.
PATRICi 32208798. VBIHalNea120669_2458.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OMAi PVELWGQ.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HNEA555778:GIVV-2440-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23641 / c2.

Entry informationi

Entry nameiD0KXK9_HALNC
AccessioniPrimary (citable) accession number: D0KXK9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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